Reaction profile

The FDA adverse-event record for ineffective, euthanasia

448 FDA reports name ineffective, euthanasia, a high-volume reaction in the CVM extract (VeDDRA 99105). Plate stamps and neighbourhood peers follow.

#687 of 2,481
by report volume (all reactions)
448
reports citing this reaction
95.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, EUTHANASIA has 448 reports now versus 445 in that prior snapshot: 3 more (0.7%).

Report change
+3
Death-coded reports
+3
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, EUTHANASIA changes

FDA AER · VeDDRA plate

Code 99105 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 448 reports
  • DEATH-HOT 95.5%
  • MID-PACK #687/2481
  • PHOTO-FINISH Application site grea…
  • SPECIES-DOG Dog · 290
  • DRUG-LEAD Pentobarbital Sod… · 140
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site greasy fur (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around INEFFECTIVE, EUTHANASIA

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Loss of bowel control · near449Application site grea… · near448Arched back · near448INEFFECTIVE, EUTHANAS… · thi…448Gastritis · near447Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, EUTHANASIA

INEFFECTIVE, EUTHANASIA: high death-coded share in the FDA AER plate

Signature read: INEFFECTIVE, EUTHANASIA's 95.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume is upper-third scale: 448 named reports in the openFDA extract. Death-coded share is upper-third: 428 of 448 reports (95.5% of named reports). Nearest volume peer: Application site greasy fur (±0 reports). Lead species Dog (290). Lead co-reported drug Pentobarbital Sodium + Phenytoin Sodium (140).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 290
Cat 80
Horse 50
Unknown 8
Other 6
Cattle 3
Sheep 1
Rabbit 1
Other Rodents 1
Fish 1

Breeds Most Affected

Unknown 52
Dog (unknown) 48
Domestic Shorthair 36
Mixed (Dog) 32
Retriever - Labrador 26
Crossbred Canine/dog 22
Cat (unknown) 18
Shepherd Dog - German 16
Horse (unknown) 15
Retriever - Golden 12

Associated Drugs

Pentobarbital Sodium + Phenytoin Sodium 140
Pentobarbital Sodium, Phenytoin Sodium 132
Pentobarbital, Phenytoin 74
Pentobarbital/Phenytoin Inj 60
Pentobarbital + Phenytoin 21
Pentobarbital 15
Ketamine 5
Pentobarbital Sodium 2
Propofol 2
Xylazine 2
Midazolam 2
Detomidine Hydrochloride 1
Xylazine Hcl 1
Tiletamine Hcl And Zolazepam Hcl 1
Melarsomine Dihydrochloride Injection 1
Ivermectin + Pyrantel As Pamoate Salt 1
Tilmicosin 1
Dexmedetomidine 1
Pentobarbital Sodium And Phenytoin Sodium 1
Butorphanol Tartrate 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, EUTHANASIA, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (448 here).

Similar death-coded share

Nearest other reactions by death-coded share (95.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, EUTHANASIA (#687 of 2,481 by report volume); death-coded 95.5%. PlainBreed reaction plate · death-coded share stamp 95.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →