INEFFECTIVE, EUTHANASIA

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VeDDRA Code: 99105

445 adverse event reports referencing this reaction

445
Total Reports
425
Deaths
9550.0%
Death Rate

Species Most Affected

Dog 290
Cat 80
Horse 50
Unknown 8
Other 6
Cattle 3
Sheep 1
Rabbit 1
Other Rodents 1
Fish 1

Breeds Most Affected

Unknown 50
Dog (unknown) 48
Domestic Shorthair 36
Mixed (Dog) 32
Retriever - Labrador 26
Crossbred Canine/dog 22
Cat (unknown) 18
Shepherd Dog - German 16
Horse (unknown) 15
Retriever - Golden 12

Associated Drugs

Pentobarbital Sodium + Phenytoin Sodium 137
Pentobarbital Sodium, Phenytoin Sodium 132
Pentobarbital, Phenytoin 74
Pentobarbital/Phenytoin Inj 60
Pentobarbital + Phenytoin 21
Pentobarbital 15
Ketamine 5
Pentobarbital Sodium 2
Propofol 2
Xylazine 2
Midazolam 2
Detomidine Hydrochloride 1
Xylazine Hcl 1
Tiletamine Hcl And Zolazepam Hcl 1
Melarsomine Dihydrochloride Injection 1
Ivermectin + Pyrantel As Pamoate Salt 1
Tilmicosin 1
Dexmedetomidine 1
Pentobarbital Sodium And Phenytoin Sodium 1
Butorphanol Tartrate 1

Data Summary

Metric Value
Total reports referencing reaction 445
Reports with fatal outcome 425
Case-fatality rate (reported events) 9550.0%
Species observed 10
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 99105.

INEFFECTIVE, EUTHANASIA Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 445 adverse event reports that reference INEFFECTIVE, EUTHANASIA as a reaction term, including 425 reports with a death outcome — a 9550.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 99105, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

INEFFECTIVE, EUTHANASIA appears most frequently in reports for Dog (290 reports), Cat (80 reports), Horse (50 reports) — with Dog dominating at 290 entries. Within those species, the breeds most often named alongside this reaction are Unknown (50), Dog (unknown) (48), Domestic Shorthair (36). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with INEFFECTIVE, EUTHANASIA are Pentobarbital Sodium + Phenytoin Sodium (137 reports), Pentobarbital Sodium, Phenytoin Sodium (132 reports), Pentobarbital, Phenytoin (74 reports), Pentobarbital/Phenytoin Inj (60 reports), with Pentobarbital Sodium + Phenytoin Sodium appearing alongside this reaction in 137 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial