Reaction profile

The FDA adverse-event record for ineffective, euthanasia

445 FDA adverse-event reports reference ineffective, euthanasia (VeDDRA 99105). See the species, breeds, and drugs most associated with it below.

445
reports citing this reaction
95.5%
death-coded share
Dog
most-affected species
Pentobarbital Sodium + Phenytoin Sodium
most-associated drug
Verify with FDA CVM →
445
Total Reports
425
Deaths
95.5%
Death Rate

Species Most Affected

Dog 290
Cat 80
Horse 50
Unknown 8
Other 6
Cattle 3
Sheep 1
Rabbit 1
Other Rodents 1
Fish 1

Breeds Most Affected

Unknown 50
Dog (unknown) 48
Domestic Shorthair 36
Mixed (Dog) 32
Retriever - Labrador 26
Crossbred Canine/dog 22
Cat (unknown) 18
Shepherd Dog - German 16
Horse (unknown) 15
Retriever - Golden 12

Associated Drugs

Pentobarbital Sodium + Phenytoin Sodium 137
Pentobarbital Sodium, Phenytoin Sodium 132
Pentobarbital, Phenytoin 74
Pentobarbital/Phenytoin Inj 60
Pentobarbital + Phenytoin 21
Pentobarbital 15
Ketamine 5
Pentobarbital Sodium 2
Propofol 2
Xylazine 2
Midazolam 2
Detomidine Hydrochloride 1
Xylazine Hcl 1
Tiletamine Hcl And Zolazepam Hcl 1
Melarsomine Dihydrochloride Injection 1
Ivermectin + Pyrantel As Pamoate Salt 1
Tilmicosin 1
Dexmedetomidine 1
Pentobarbital Sodium And Phenytoin Sodium 1
Butorphanol Tartrate 1

INEFFECTIVE, EUTHANASIA Reaction Insights

445 reports name INEFFECTIVE, EUTHANASIA; 425 recorded a death outcome (95.5% of reported events, not a population-level mortality rate). VeDDRA code: 99105.

By species: Dog (290 reports), Cat (80 reports), Horse (50 reports). By breed: Unknown (50), Dog (unknown) (48), Domestic Shorthair (36).

Most co-reported drugs: Pentobarbital Sodium + Phenytoin Sodium (137 reports), Pentobarbital Sodium, Phenytoin Sodium (132 reports), Pentobarbital, Phenytoin (74 reports), Pentobarbital/Phenytoin Inj (60 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.