Reaction profile

The FDA adverse-event record for blood and lymphatic system disorder nos

369 FDA reports name blood and lymphatic system disorder nos, a high-volume reaction in the CVM extract (VeDDRA 148). Plate stamps and neighbourhood peers follow.

#775 of 2,481
by report volume (all reactions)
369
reports citing this reaction
33.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Blood and lymphatic system disorder NOS has 369 reports now versus 367 in that prior snapshot: 2 more (0.5%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Blood and lymphatic system disorder NOS changes

FDA AER · VeDDRA plate

Code 148 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 369 reports
  • DEATH-HOT 33.3%
  • MID-PACK #775/2481
  • PHOTO-FINISH Tenesmus
  • SPECIES-DOG Dog · 324
  • DRUG-LEAD Milbemycin Oxime… · 89
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Tenesmus (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Blood and lymphatic system disorder NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Blood and lymphatic s… · thi…369Tenesmus · near369Abdominal cavity haem… · near368Jaw disorder · near368Lot # and/or Expirati… · near368Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Blood and lymphatic system disorder NOS

Blood and lymphatic system disorder NOS: high death-coded share in the FDA AER plate

Signature read: 123 death-coded reports is a heavy tail count for Blood and lymphatic system disorder NOS in the CVM extract. Report volume is upper-third scale: 369 named reports in the openFDA extract. Death-coded share is upper-third: 123 of 369 reports (33.3% of named reports). Nearest volume peer: Tenesmus (±0 reports). Lead species Dog (324). Lead co-reported drug Milbemycin Oxime + Spinosad (89).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 324
Cat 37
Horse 5
Cattle 3

Breeds Most Affected

Retriever - Labrador 36
Crossbred Canine/dog 26
Shepherd Dog - German 18
Terrier - Yorkshire 17
Domestic Shorthair 16
Shih Tzu 11
Beagle 9
Boxer (German Boxer) 8
Rottweiler 8
Dog (unknown) 8

Associated Drugs

Milbemycin Oxime + Spinosad 89
Carprofen 51
Spinosad 42
Trilostane 24
Oclacitinib Maleate 22
Maropitant Citrate 16
Prednisone 13
Cefovecin 11
Ivermectin + Pyrantel As Pamoate Salt 11
Deracoxib 10
Meloxicam 10
Afoxolaner 10
Rabies Vaccine 9
Cefpodoxime Proxetil 8
Fluralaner Chew Tablets 8
Cyclosporine 7
Firocoxib 7
Moxidectin 7
Famotidine 7
Isoflurane 6

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Blood and lymphatic system disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (369 here).

Similar death-coded share

Nearest other reactions by death-coded share (33.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Blood and lymphatic system disorder NOS (#775 of 2,481 by report volume); death-coded 33.3%. PlainBreed reaction plate · death-coded report count stamp 123 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →