Reaction profile

The FDA adverse-event record for blood and lymphatic system disorder nos

367 FDA adverse-event reports reference blood and lymphatic system disorder nos (VeDDRA 148). See the species, breeds, and drugs most associated with it below.

367
reports citing this reaction
33.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
367
Total Reports
123
Deaths
33.5%
Death Rate

Species Most Affected

Dog 322
Cat 37
Horse 5
Cattle 3

Breeds Most Affected

Retriever - Labrador 36
Crossbred Canine/dog 26
Shepherd Dog - German 18
Terrier - Yorkshire 17
Domestic Shorthair 16
Shih Tzu 11
Beagle 9
Boxer (German Boxer) 8
Rottweiler 8
Dog (unknown) 8

Associated Drugs

Milbemycin Oxime + Spinosad 89
Carprofen 51
Spinosad 42
Trilostane 24
Oclacitinib Maleate 22
Maropitant Citrate 16
Prednisone 13
Cefovecin 11
Deracoxib 10
Meloxicam 10
Ivermectin + Pyrantel As Pamoate Salt 10
Afoxolaner 10
Rabies Vaccine 9
Cefpodoxime Proxetil 8
Fluralaner Chew Tablets 8
Firocoxib 7
Cyclosporine 7
Moxidectin 7
Famotidine 7
Isoflurane 6

Blood and lymphatic system disorder NOS Reaction Insights

367 reports name Blood and lymphatic system disorder NOS; 123 recorded a death outcome (33.5% of reported events, not a population-level mortality rate). VeDDRA code: 148.

By species: Dog (322 reports), Cat (37 reports), Horse (5 reports). By breed: Retriever - Labrador (36), Crossbred Canine/dog (26), Shepherd Dog - German (18).

Most co-reported drugs: Milbemycin Oxime + Spinosad (89 reports), Carprofen (51 reports), Spinosad (42 reports), Trilostane (24 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.