Reaction profile

The FDA adverse-event record for hypoaesthesia

58 FDA adverse-event reports reference hypoaesthesia (VeDDRA 1957). See the species, breeds, and drugs most associated with it below.

58
reports citing this reaction
10.3%
death-coded share
Human
most-affected species
Ivermectin
most-associated drug
Verify with FDA CVM →
58
Total Reports
6
Deaths
10.3%
Death Rate

Species Most Affected

Human 42
Dog 12
Horse 2
Guinea Pig 1
Cat 1

Breeds Most Affected

Unknown 43
Retriever - Labrador 5
Poodle (unspecified) 1
Dog (unknown) 1
Horse (unknown) 1
Dachshund (unspecified) 1
Thoroughbred 1
Domestic (unspecified) 1
Shepherd Dog (unspecified) 1
Crossbred Canine/dog 1

Associated Drugs

Ivermectin 6
Imidacloprid, Moxidectin 5
Tilmicosin Phosphate 4
Dexmedetomidine Hydrochloride 4
Spinosad 3
Ivermectin, Praziquantel 3
Pentobarbital, Phenytoin 3
Bedinvetmab 3
Florfenicol 2
Maropitant 2
Selamectin 2
Enrofloxacin 1
Deracoxib 1
Tiletamine, Zolazepam 1
Ceftiofur Hydrochloride 1
Ceftiofur 1
Nitenpyram 1
Milbemycin, Lufenuron 1
Imidacloprid + Moxidectin 1
Doramectin 1

Hypoaesthesia Reaction Insights

58 reports name Hypoaesthesia; 6 recorded a death outcome (10.3% of reported events, not a population-level mortality rate). VeDDRA code: 1957.

By species: Human (42 reports), Dog (12 reports), Horse (2 reports). By breed: Unknown (43), Retriever - Labrador (5), Poodle (unspecified) (1).

Most co-reported drugs: Ivermectin (6 reports), Imidacloprid, Moxidectin (5 reports), Tilmicosin Phosphate (4 reports), Dexmedetomidine Hydrochloride (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.