Reaction profile

The FDA adverse-event record for salivary gland disorder

57 FDA adverse-event reports reference salivary gland disorder (VeDDRA 2383). See the species, breeds, and drugs most associated with it below.

57
reports citing this reaction
10.5%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
57
Total Reports
6
Deaths
10.5%
Death Rate

Species Most Affected

Dog 53
Human 2
Cat 2

Breeds Most Affected

Terrier - Boston 5
Chihuahua 5
Dachshund - Miniature 4
Maltese 3
Unknown 3
Retriever - Labrador 3
Shepherd Dog - German 3
Dachshund (unspecified) 2
Boxer (German Boxer) 2
Bulldog - French 2

Associated Drugs

Trilostane 17
Oclacitinib Maleate 8
Carprofen 6
Anti-Il31 Mab Mcs Lot #1283563 5
Milbemycin Oxime + Spinosad 4
Maropitant Citrate 4
Famotidine 4
Moxidectin 4
Prednisone 3
Capromorelin Tartrate 3
Buprenorphine 3
Hydroxyzine 2
Fluralaner Chew Tablets 2
Milbemycin Oxime + Praziquantel 2
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 2
Diphenhydramine Hcl 2
Metronidazole 2
Fluralaner 13.64% 12-Week Chew 2
Tylosin Tartrate 2
Enrofloxacin 2

Salivary gland disorder Reaction Insights

57 reports name Salivary gland disorder; 6 recorded a death outcome (10.5% of reported events, not a population-level mortality rate). VeDDRA code: 2383.

By species: Dog (53 reports), Human (2 reports), Cat (2 reports). By breed: Terrier - Boston (5), Chihuahua (5), Dachshund - Miniature (4).

Most co-reported drugs: Trilostane (17 reports), Oclacitinib Maleate (8 reports), Carprofen (6 reports), Anti-Il31 Mab Mcs Lot #1283563 (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.