Reaction profile

The FDA adverse-event record for flaking skin

Name: Flaking skin - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

1,102 FDA reports name flaking skin, a high-volume reaction in the CVM extract (VeDDRA 1474). Plate stamps and neighbourhood peers follow.

#368 of 2,481
by report volume (all reactions): 1,102
reports citing this reaction: 3.1%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Flaking skin has 1,102 reports now versus 1,087 in that prior snapshot: 15 more (1.4%).

Report change: +15
Death-coded reports: +1
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Flaking skin changes

FDA AER · VeDDRA plate

Code 1474 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-MID 1,102 reports
DEATH-LOW 3.1%
UPPER-Q #368/2481
PHOTO-FINISH Electrolyte disorder
SPECIES-DOG Dog · 943
DRUG-LEAD Afoxolaner · 335
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Electrolyte disorder (±3 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Flaking skin

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Flaking skin

Flaking skin: low death-coded share in the FDA AER plate

Signature read: 1,102 reports place Flaking skin in the upper third of FDA AER volume (#368 of 2,481). Report volume is upper-third scale: 1,102 named reports in the openFDA extract. Death-coded share is lower-third: 34 of 1,102 reports (3.1% of named reports). Nearest volume peer: Electrolyte disorder (±3 reports). Lead species Dog (943). Lead co-reported drug Afoxolaner (335).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 943

Cat 129

Cattle 15

Horse 8

Human 4

Rabbit 2

Goat 1

Breeds Most Affected

Retriever - Labrador 132

Crossbred Canine/dog 88

Domestic Shorthair 74

Shepherd Dog - German 57

Retriever - Golden 51

Shih Tzu 41

Chihuahua 38

Dog (unknown) 34

Terrier - Yorkshire 27

Pit Bull 22

Associated Drugs

Afoxolaner 335

Ivermectin + Pyrantel As Pamoate Salt 88

Trilostane 80

Milbemycin Oxime + Spinosad 72

Oclacitinib Maleate 59

Fluralaner Chew Tablets 50

Selamectin 47

Prednisone 36

Bedinvetmab 36

Spinosad 32

Carprofen 29

Fluralaner 13.64% 12-Week Chew 28

Fluralaner Spot-On Solution 26

Imidacloprid + Moxidectin 23

Anti-Il31 Mab Mcs Lot #1283563 23

Gabapentin 17

Sarolaner 16

Pyrantel Pamoate;Sarolaner 16

Fipronil 10%/S Methoprene 9% Spot On 13

Cefovecin 12

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Flaking skin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,102 here).

Electrolyte disorder 1,105 Skin irritation 1,098 Faecal incontinence 1,107 Dermal mass 1,109

Similar death-coded share

Nearest other reactions by death-coded share (3.1% here), distinct from the volume row.

Partial lack of efficacy 3.1% Hair loss NOS 3.1% Acting tense 3.1% Lip licking 3.1%

What to do with this reaction

Compare Flaking skin's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Flaking skin (#368 of 2,481 by report volume); death-coded 3.1%. PlainBreed reaction plate · report volume stamp 1,102 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →