Reaction profile

The FDA adverse-event record for electrolyte disorder

1,075 FDA adverse-event reports reference electrolyte disorder (VeDDRA 2144). See the species, breeds, and drugs most associated with it below.

1,075
reports citing this reaction
23.8%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
1,075
Total Reports
256
Deaths
23.8%
Death Rate

Species Most Affected

Dog 944
Cat 119
Horse 12

Breeds Most Affected

Retriever - Labrador 80
Domestic Shorthair 73
Chihuahua 48
Crossbred Canine/dog 44
Terrier - Yorkshire 42
Maltese 39
Terrier - Boston 34
Shih Tzu 31
Beagle 27
Dachshund - Miniature 26

Associated Drugs

Trilostane 607
Milbemycin Oxime + Spinosad 134
Maropitant Citrate 64
Spinosad 52
Prednisone 51
Carprofen 48
Meloxicam 35
Desoxycorticosterone Pivalate 30
Desoxycortone 28
Oclacitinib Maleate 25
Tramadol 24
Insulin 22
Cefovecin 22
Gabapentin 22
Bedinvetmab 22
Buprenorphine 19
Deracoxib 19
Famotidine 17
Afoxolaner 17
Selamectin 15

Electrolyte disorder Reaction Insights

1,075 reports name Electrolyte disorder; 256 recorded a death outcome (23.8% of reported events, not a population-level mortality rate). VeDDRA code: 2144.

By species: Dog (944 reports), Cat (119 reports), Horse (12 reports). By breed: Retriever - Labrador (80), Domestic Shorthair (73), Chihuahua (48).

Most co-reported drugs: Trilostane (607 reports), Milbemycin Oxime + Spinosad (134 reports), Maropitant Citrate (64 reports), Spinosad (52 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.