Reaction profile

The FDA adverse-event record for acting tense

93 FDA adverse-event reports reference acting tense (VeDDRA 2206). See the species, breeds, and drugs most associated with it below.

93
reports citing this reaction
3.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Praziquantel
most-associated drug
Verify with FDA CVM →
93
Total Reports
3
Deaths
3.2%
Death Rate

Species Most Affected

Dog 76
Cat 16
Human 1

Breeds Most Affected

Crossbred Canine/dog 8
Domestic Shorthair 8
Retriever - Labrador 8
Terrier (unspecified) 5
Dog (unknown) 4
Chihuahua 4
Siberian Husky 3
Maltese 3
Terrier - Jack Russell 3
Retriever - Golden 3

Associated Drugs

Milbemycin Oxime + Praziquantel 9
Selamectin 7
Buprenorphine 7
Pyrantel Pamoate;Sarolaner 7
Carprofen 6
Milbemycin Oxime + Spinosad 5
Maropitant Citrate 5
Fluralaner Chew Tablets 5
Sarolaner 5
Dexmedetomidine 5
Imidacloprid + Moxidectin 5
Fluralaner 13.64% 12-Week Chew 5
Spinosad 4
Afoxolaner 4
Oclacitinib Maleate 4
Gabapentin 4
Robenacoxib 4
Propofol 4
Ketamine 4
Famotidine 3

Acting tense Reaction Insights

93 reports name Acting tense; 3 recorded a death outcome (3.2% of reported events, not a population-level mortality rate). VeDDRA code: 2206.

By species: Dog (76 reports), Cat (16 reports), Human (1 reports). By breed: Crossbred Canine/dog (8), Domestic Shorthair (8), Retriever - Labrador (8).

Most co-reported drugs: Milbemycin Oxime + Praziquantel (9 reports), Selamectin (7 reports), Buprenorphine (7 reports), Pyrantel Pamoate;Sarolaner (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.