Reaction profile

The FDA adverse-event record for partial lack of efficacy

3,031 FDA adverse-event reports reference partial lack of efficacy (VeDDRA 2001). See the species, breeds, and drugs most associated with it below.

3,031
reports citing this reaction
3.2%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
3,031
Total Reports
98
Deaths
3.2%
Death Rate

Species Most Affected

Dog 2,275
Cat 461
Horse 239
Cattle 42
Unknown 3
Sheep 3
Other Birds 1
Other Mammals 1
Pig 1
Fish 1

Breeds Most Affected

Retriever - Labrador 312
Domestic Shorthair 251
Dog (unknown) 156
Shepherd Dog - German 145
Crossbred Canine/dog 115
Retriever - Golden 108
Terrier - Bull - American Pit 68
Chihuahua 66
Shih Tzu 59
Quarter Horse 58

Associated Drugs

Bedinvetmab 900
Oclacitinib Maleate 533
Frunevetmab 275
Gabapentin 236
Omeprazole 209
Carprofen 153
Anti-Il31 Mab Mcs Lot #1283563 153
Nitenpyram 124
Grapiprant 85
Lotilaner 58
Polysulfated Glycosaminoglycan 57
Milbemycin Oxime + Praziquantel 55
Galliprant 50
Prednisone 46
Ivermectin + Pyrantel As Pamoate Salt 45
Sucralfate 44
Fluralaner Chew Tablets 41
Betamethasone + Florfenicol + Terbinafine 40
Afoxolaner 38
Isoflurane 37

Partial lack of efficacy Reaction Insights

3,031 reports name Partial lack of efficacy; 98 recorded a death outcome (3.2% of reported events, not a population-level mortality rate). VeDDRA code: 2001.

By species: Dog (2,275 reports), Cat (461 reports), Horse (239 reports). By breed: Retriever - Labrador (312), Domestic Shorthair (251), Dog (unknown) (156).

Most co-reported drugs: Bedinvetmab (900 reports), Oclacitinib Maleate (533 reports), Frunevetmab (275 reports), Gabapentin (236 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.