Reaction profile

The FDA adverse-event record for elevated bun

72 FDA adverse-event reports reference elevated bun (VeDDRA 2047). See the species, breeds, and drugs most associated with it below.

72
reports citing this reaction
38.9%
death-coded share
Dog
most-affected species
Grapiprant
most-associated drug
Verify with FDA CVM →
72
Total Reports
28
Deaths
38.9%
Death Rate

Species Most Affected

Dog 65
Cat 7

Breeds Most Affected

Retriever - Labrador 10
Retriever - Golden 9
Terrier - Yorkshire 4
Terrier (unspecified) 3
Domestic Shorthair 3
Hound - Basset 2
Shepherd Dog - Australian 2
Brittany 2
Domestic Longhair 2
Beagle 2

Associated Drugs

Grapiprant 40
Tramadol 11
Gabapentin 9
Carprofen 8
Milbemycin Oxime + Spinosad 6
Deracoxib 6
Robenacoxib 5
Polysulfated Glycosaminoglycan 5
Spinosad 4
Famotidine 4
Trilostane 4
Firocoxib 3
Amlodipine 2
Phenylpropanolamine Hcl 2
Milbemycin Oxime + Lufenuron 2
Maropitant Citrate 2
Cefovecin 2
Levothyroxine 2
Metronidazole 2
Oclacitinib 2

Elevated BUN Reaction Insights

72 reports name Elevated BUN; 28 recorded a death outcome (38.9% of reported events, not a population-level mortality rate). VeDDRA code: 2047.

By species: Dog (65 reports), Cat (7 reports). By breed: Retriever - Labrador (10), Retriever - Golden (9), Terrier - Yorkshire (4).

Most co-reported drugs: Grapiprant (40 reports), Tramadol (11 reports), Gabapentin (9 reports), Carprofen (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.