Reaction profile

The FDA adverse-event record for ear flapping/twitching

69 FDA adverse-event reports reference ear flapping/twitching (VeDDRA 1986). See the species, breeds, and drugs most associated with it below.

69
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
69
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 45
Cat 22
Horse 2

Breeds Most Affected

Domestic Shorthair 11
Retriever - Golden 7
Crossbred Canine/dog 4
Retriever - Labrador 4
Pit Bull 4
Domestic Longhair 4
Dachshund (unspecified) 2
Boxer (German Boxer) 2
Terrier - Cairn 2
Cat (other) 2

Associated Drugs

Milbemycin Oxime + Spinosad 6
Afoxolaner 6
Spinosad 5
Ivermectin + Pyrantel As Pamoate Salt 5
Selamectin 4
Nitenpyram 4
Fluralaner 13.64% 12-Week Chew 3
Mirtazapine 3
Selamectin;Sarolaner 3
Maropitant 2
Cefovecin 2
Ivermectin, Pyrantel 2
Meloxicam 2
Fluralaner Chew Tablets 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Eprinomectin + Esafoxolaner + Praziquantel 2
Dexamethasone 1
Antibiotic (Unknown) 1
Ivermectin + Pyrantel Pamoate 1
Ivermectin Tablets 136 Mcg 1

Ear flapping/twitching Reaction Insights

69 reports name Ear flapping/twitching; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 1986.

By species: Dog (45 reports), Cat (22 reports), Horse (2 reports). By breed: Domestic Shorthair (11), Retriever - Golden (7), Crossbred Canine/dog (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (6 reports), Afoxolaner (6 reports), Spinosad (5 reports), Ivermectin + Pyrantel As Pamoate Salt (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.