Elevated serum alkaline phosphatase (SAP)

VeDDRA Code: 2055

11,296 adverse event reports referencing this reaction

11,296

Total Reports

2,127

Deaths

1880.0%

Death Rate

Species Most Affected

Dog 10,951

Cat 321

Horse 16

Cattle 5

Other 1

Other Canids 1

Pig 1

Breeds Most Affected

Retriever - Labrador 1,839

Crossbred Canine/dog 865

Chihuahua 402

Shih Tzu 400

Maltese 315

Retriever - Golden 312

Beagle 293

Terrier - Yorkshire 241

Dachshund (unspecified) 219

Boxer (German Boxer) 213

Associated Drugs

Trilostane 2,413

Carprofen 2,370

Oclacitinib Maleate 1,023

Milbemycin Oxime + Spinosad 757

Maropitant Citrate 745

Afoxolaner 494

Fluralaner Chew Tablets 427

Prednisone 396

Moxidectin 380

Deracoxib 361

Spinosad 341

Grapiprant 323

Meloxicam 297

Tramadol 297

Gabapentin 296

Ivermectin + Pyrantel As Pamoate Salt 294

Famotidine 270

Metronidazole 251

Cyclosporine 236

Firocoxib 227

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.