Cardiac disorder NOS

Cardiac disorder NOS Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 11,478 adverse event reports that reference Cardiac disorder NOS as a reaction term, including 701 reports with a death outcome — a 610.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 202, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Cardiac disorder NOS appears most frequently in reports for Dog (11,103 reports), Cat (224 reports), Cattle (101 reports) — with Dog dominating at 11,103 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (2,755), Crossbred Canine/dog (1,388), Shepherd Dog - German (825). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Cardiac disorder NOS are Ivermectin + Pyrantel As Pamoate Salt (6,766 reports), Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg (1,897 reports), Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg (619 reports), Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg (528 reports), with Ivermectin + Pyrantel As Pamoate Salt appearing alongside this reaction in 6,766 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.