Reaction profile

The FDA adverse-event record for cardiac disorder nos

11,531 FDA reports name cardiac disorder nos, a high-volume reaction in the CVM extract (VeDDRA 202). Plate stamps and neighbourhood peers follow.

#37 of 2,481
by report volume (all reactions)
11,531
reports citing this reaction
6.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cardiac disorder NOS has 11,531 reports now versus 11,516 in that prior snapshot: 15 more (0.1%).

Report change
+15
Death-coded reports
+9
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cardiac disorder NOS changes

FDA AER · VeDDRA plate

Code 202 VOL-HIGH

VOL-HIGH · DEATH-PAR · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 11,531 reports
  • DEATH-PAR 6.3%
  • TOP-DECILE #37/2481
  • PHOTO-FINISH Vocalisation
  • SPECIES-DOG Dog · 11,132
  • DRUG-LEAD Ivermectin + Pyra… · 6,766
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Vocalisation (±168 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Cardiac disorder NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lack of efficacy (bac… · near12011Cardiac disorder NOS · this …11531Vocalisation · near11363Elevated serum alkali… · near11291Fever · near11181Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cardiac disorder NOS

Cardiac disorder NOS: low death-coded share in the FDA AER plate

Signature read: 11,531 reports place Cardiac disorder NOS in the upper third of FDA AER volume (#37 of 2,481). Report volume is upper-third scale: 11,531 named reports in the openFDA extract. Death-coded share is lower-third: 729 of 11,531 reports (6.3% of named reports). Nearest volume peer: Vocalisation (±168 reports). Lead species Dog (11,132). Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt (6,766).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 11,132
Cat 238
Cattle 107
Horse 10
Pig 10
Human 7
Sheep 5
Goat 3
Turkey 2
Lion 2

Breeds Most Affected

Retriever - Labrador 2,756
Crossbred Canine/dog 1,388
Shepherd Dog - German 826
Beagle 410
Retriever - Golden 391
Boxer (German Boxer) 349
Pit Bull 330
Dog (unknown) 225
Collie - Border 209
Chihuahua 195

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 6,766
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 1,897
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 619
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 528
Melarsomine Dihydrochloride Injection 458
Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg 441
Milbemycin Oxime + Spinosad 162
Ivermectin/Pyrantel Chew. Dog 136Mcg/114Mg 133
Ivermectin/Pyrantel Chew. Dog 68Mcg/57Mg 117
Monensin Sodium 102
Melarsomine 99
Spinosad 86
Carprofen 66
Maropitant Citrate 66
Ivermectin + Pyrantel 55
Afoxolaner 50
Buprenorphine 47
Moxidectin 44
Isoflurane 42
Trilostane 41

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Cardiac disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (6.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cardiac disorder NOS (#37 of 2,481 by report volume); death-coded 6.3%. PlainBreed reaction plate · report volume stamp 11,531 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →