Reaction profile

The FDA adverse-event record for fever

10,767 FDA adverse-event reports reference fever (VeDDRA 1032). See the species, breeds, and drugs most associated with it below.

10,767
reports citing this reaction
15.3%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
10,767
Total Reports
1,645
Deaths
15.3%
Death Rate

Species Most Affected

Dog 7,445
Cat 2,610
Horse 454
Cattle 168
Human 55
Sheep 7
Pig 7
Goat 6
Unknown 3
Donkey 2

Breeds Most Affected

Domestic Shorthair 1,353
Retriever - Labrador 901
Crossbred Canine/dog 619
Retriever - Golden 370
Shepherd Dog - German 327
Domestic (unspecified) 318
Chihuahua 285
Terrier - Yorkshire 254
Domestic Longhair 226
Boxer (German Boxer) 212

Associated Drugs

Moxidectin 1,246
Maropitant Citrate 804
Milbemycin Oxime + Spinosad 774
Carprofen 656
Cefovecin 580
Selamectin 518
Oclacitinib Maleate 453
Afoxolaner 436
Buprenorphine 393
Spinosad 346
Prednisone 324
Fluralaner Chew Tablets 297
Meloxicam 287
Bedinvetmab 287
Gabapentin 272
Pyrantel Pamoate;Sarolaner 264
Melarsomine Dihydrochloride 251
Robenacoxib 245
Enrofloxacin 230
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 227

Fever Reaction Insights

10,767 reports name Fever; 1,645 recorded a death outcome (15.3% of reported events, not a population-level mortality rate). VeDDRA code: 1032.

By species: Dog (7,445 reports), Cat (2,610 reports), Horse (454 reports). By breed: Domestic Shorthair (1,353), Retriever - Labrador (901), Crossbred Canine/dog (619).

Most co-reported drugs: Moxidectin (1,246 reports), Maropitant Citrate (804 reports), Milbemycin Oxime + Spinosad (774 reports), Carprofen (656 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.