Reaction profile

The FDA adverse-event record for fever

11,181 FDA reports name fever, a high-volume reaction in the CVM extract (VeDDRA 1032). Plate stamps and neighbourhood peers follow.

#40 of 2,481
by report volume (all reactions)
11,181
reports citing this reaction
15.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Fever has 11,181 reports now versus 11,023 in that prior snapshot: 158 more (1.4%).

Report change
+158
Death-coded reports
+24
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Fever changes

FDA AER · VeDDRA plate

Code 1032 VOL-HIGH

VOL-HIGH · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 11,181 reports
  • DEATH-ELEV 15.2%
  • TOP-DECILE #40/2481
  • PHOTO-FINISH Elevated serum alkali…
  • SPECIES-DOG Dog · 7,696
  • DRUG-LEAD Moxidectin · 1,280
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated serum alkaline phosphatase (SAP) (±110 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Fever

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Cardiac disorder NOS · near11531Vocalisation · near11363Elevated serum alkali… · near11291Fever · this reaction11181Underdose · near10973Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Fever

What the FDA AER plate says about Fever

Signature read: 1,701 death-coded reports is a heavy tail count for Fever in the CVM extract. Report volume is upper-third scale: 11,181 named reports in the openFDA extract. 1,701 of 11,181 reports were death-coded (15.2% of named reports, not a population mortality rate). Nearest volume peer: Elevated serum alkaline phosphatase (SAP) (±110 reports). Lead species Dog (7,696). Lead co-reported drug Moxidectin (1,280).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 7,696
Cat 2,738
Horse 486
Cattle 170
Human 56
Sheep 7
Pig 7
Goat 6
Unknown 3
Donkey 2

Breeds Most Affected

Domestic Shorthair 1,436
Retriever - Labrador 932
Crossbred Canine/dog 638
Retriever - Golden 386
Shepherd Dog - German 341
Domestic (unspecified) 320
Chihuahua 290
Terrier - Yorkshire 261
Domestic Longhair 233
Boxer (German Boxer) 217

Associated Drugs

Moxidectin 1,280
Maropitant Citrate 881
Milbemycin Oxime + Spinosad 777
Carprofen 694
Cefovecin 600
Selamectin 519
Oclacitinib Maleate 473
Afoxolaner 448
Buprenorphine 426
Prednisone 360
Spinosad 346
Bedinvetmab 322
Gabapentin 317
Fluralaner Chew Tablets 297
Meloxicam 296
Pyrantel Pamoate;Sarolaner 280
Robenacoxib 275
Melarsomine Dihydrochloride 261
Enrofloxacin 260
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 235

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Fever, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (15.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Fever (#40 of 2,481 by report volume); death-coded 15.2%. PlainBreed reaction plate · death-coded report count stamp 1,701 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →