Reaction profile
The FDA adverse-event record for elevated liver enzymes
5,735 FDA reports name elevated liver enzymes, a high-volume reaction in the CVM extract (VeDDRA 1942). Plate stamps and neighbourhood peers follow.
- #86 of 2,481
- by report volume (all reactions)
- 5,735
- reports citing this reaction
- 18.9%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Elevated liver enzymes has 5,735 reports now versus 5,735 in that prior snapshot: 0 the same number of (0.0%).
- Report change
- +0
- Death-coded reports
- +0
- Death-coded share
- +0.0 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Elevated liver enzymes changesFDA AER · VeDDRA plate
Code 1942 VOL-HIGH
VOL-HIGH · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-HIGH 5,735 reports
- DEATH-ELEV 18.9%
- TOP-DECILE #86/2481
- PHOTO-FINISH Inappropriate urinati…
- SPECIES-DOG Dog · 5,315
- DRUG-LEAD Carprofen · 1,332
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Inappropriate urination (±51 reports)
Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.
High-volume neighbourhood around Elevated liver enzymes
Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.
What the FDA AER plate says about Elevated liver enzymes
Signature read: 1,082 death-coded reports is a heavy tail count for Elevated liver enzymes in the CVM extract. Report volume is upper-third scale: 5,735 named reports in the openFDA extract. 1,082 of 5,735 reports were death-coded (18.9% of named reports, not a population mortality rate). Nearest volume peer: Inappropriate urination (±51 reports). Lead species Dog (5,315). Lead co-reported drug Carprofen (1,332).
Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Carprofen appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Elevated liver enzymes, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (5,735 here).
Similar death-coded share
Nearest other reactions by death-coded share (18.9% here), distinct from the volume row.
What to do with this reaction
- Compare Elevated liver enzymes's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →