Reaction profile

The FDA adverse-event record for facial oedema

1,921 FDA adverse-event reports reference facial oedema (VeDDRA 1110). See the species, breeds, and drugs most associated with it below.

1,921
reports citing this reaction
4.6%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
1,921
Total Reports
89
Deaths
4.6%
Death Rate

Species Most Affected

Dog 1,662
Cat 114
Horse 109
Cattle 30
Human 4
Sheep 2

Breeds Most Affected

Retriever - Labrador 205
Crossbred Canine/dog 198
Boxer (German Boxer) 115
Chihuahua 107
Dachshund (unspecified) 75
Retriever - Golden 58
Terrier - Bull - American Pit 53
Dog (unknown) 51
Domestic Shorthair 47
Pit Bull 46

Associated Drugs

Moxidectin 596
Carprofen 82
Melarsomine Dihydrochloride 76
Maropitant Citrate 64
Milbemycin Oxime + Spinosad 61
Afoxolaner 57
Spinosad 52
Maropitant 49
Melarsomine Dihydrochloride Injection 48
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 47
Rabies Virus, Kv 44
Meloxicam 41
Diphenhydramine Hcl 39
Cefovecin Sodium 37
Ivermectin, Pyrantel 34
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 34
Selamectin 33
Ivermectin + Pyrantel As Pamoate Salt 31
Ivermectin 30
Prednisone 28

Facial oedema Reaction Insights

1,921 reports name Facial oedema; 89 recorded a death outcome (4.6% of reported events, not a population-level mortality rate). VeDDRA code: 1110.

By species: Dog (1,662 reports), Cat (114 reports), Horse (109 reports). By breed: Retriever - Labrador (205), Crossbred Canine/dog (198), Boxer (German Boxer) (115).

Most co-reported drugs: Moxidectin (596 reports), Carprofen (82 reports), Melarsomine Dihydrochloride (76 reports), Maropitant Citrate (64 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.