Reaction profile

The FDA adverse-event record for hypoxia

163 FDA adverse-event reports reference hypoxia (VeDDRA 2186). See the species, breeds, and drugs most associated with it below.

163
reports citing this reaction
35.0%
death-coded share
Dog
most-affected species
Isoflurane
most-associated drug
Verify with FDA CVM →
163
Total Reports
57
Deaths
35.0%
Death Rate

Species Most Affected

Dog 105
Cat 42
Horse 7
Other Rodents 2
Mouse 2
Chicken 1
Unknown 1
Cattle 1
Other Bovine 1
Human 1

Breeds Most Affected

Domestic Shorthair 25
Retriever - Labrador 11
Crossbred Canine/dog 7
Spitz - German Pomeranian 6
Terrier - Yorkshire 6
Dog (unknown) 6
Chihuahua 6
Beagle 5
Bulldog - French 4
Cat (unknown) 4

Associated Drugs

Isoflurane 24
Maropitant Citrate 21
Buprenorphine 15
Dexmedetomidine Hydrochloride 14
Butorphanol 13
Midazolam 11
Carprofen 11
Propofol 11
Moxidectin 10
Sevoflurane 10
Alfaxalone 9
Atipamezole Hydrochloride 8
Ketamine 8
Melarsomine Dihydrochloride 8
Meloxicam 7
Ketamine Hydrochloride 7
Gabapentin 7
Diazepam 7
Atropine 7
Pyrantel Pamoate;Sarolaner 7

Hypoxia Reaction Insights

163 reports name Hypoxia; 57 recorded a death outcome (35.0% of reported events, not a population-level mortality rate). VeDDRA code: 2186.

By species: Dog (105 reports), Cat (42 reports), Horse (7 reports). By breed: Domestic Shorthair (25), Retriever - Labrador (11), Crossbred Canine/dog (7).

Most co-reported drugs: Isoflurane (24 reports), Maropitant Citrate (21 reports), Buprenorphine (15 reports), Dexmedetomidine Hydrochloride (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.