Reaction profile

The FDA adverse-event record for anaphylactic-type reaction

1,115 FDA adverse-event reports reference anaphylactic-type reaction (VeDDRA 1114). See the species, breeds, and drugs most associated with it below.

1,115
reports citing this reaction
13.7%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
1,115
Total Reports
153
Deaths
13.7%
Death Rate

Species Most Affected

Dog 814
Cattle 123
Horse 56
Human 48
Cat 46
Pig 20
Sheep 5
Alpaca 1
Donkey 1
Goat 1

Breeds Most Affected

Retriever - Labrador 86
Boxer (German Boxer) 57
Unknown 56
Chihuahua 52
Terrier - Bull - American Pit 50
Mixed (Cattle) 48
Crossbred Canine/dog 46
Retriever - Golden 32
Shepherd Dog - German 31
Dachshund (unspecified) 30

Associated Drugs

Moxidectin 190
Pyrantel Pamoate;Sarolaner 107
Melarsomine Dihydrochloride Injection 82
Maropitant Citrate 45
Milbemycin Oxime + Spinosad 44
Afoxolaner 41
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 37
Rabies Virus, 36
Cefovecin 35
Doramectin 31
Ivermectin + Pyrantel As Pamoate Salt 31
Melarsomine Dihydrochloride 29
Anti-Il31 Mab Mcs Lot #1283563 27
Fluralaner 13.64% 12-Week Chew 26
Lotilaner 22
Selamectin 20
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 20
Prednisone 19
Carprofen 19
Oclacitinib Maleate 19

Anaphylactic-type reaction Reaction Insights

1,115 reports name Anaphylactic-type reaction; 153 recorded a death outcome (13.7% of reported events, not a population-level mortality rate). VeDDRA code: 1114.

By species: Dog (814 reports), Cattle (123 reports), Horse (56 reports). By breed: Retriever - Labrador (86), Boxer (German Boxer) (57), Unknown (56).

Most co-reported drugs: Moxidectin (190 reports), Pyrantel Pamoate;Sarolaner (107 reports), Melarsomine Dihydrochloride Injection (82 reports), Maropitant Citrate (45 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.