Reaction profile

The FDA adverse-event record for anaphylactic-type reaction

1,132 FDA reports name anaphylactic-type reaction, a high-volume reaction in the CVM extract (VeDDRA 1114). Plate stamps and neighbourhood peers follow.

#356 of 2,481
by report volume (all reactions)
1,132
reports citing this reaction
13.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Anaphylactic-type reaction has 1,132 reports now versus 1,121 in that prior snapshot: 11 more (1.0%).

Report change
+11
Death-coded reports
+1
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Anaphylactic-type reaction changes

FDA AER · VeDDRA plate

Code 1114 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,132 reports
  • DEATH-ELEV 13.6%
  • UPPER-Q #356/2481
  • PHOTO-FINISH Injection site abscess
  • SPECIES-DOG Dog · 826
  • DRUG-LEAD Moxidectin · 193
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Injection site abscess (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Anaphylactic-type reaction

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Regurgitation · near1136Tubes, Damaged · near1136Low sodium-potassium… · near1134Anaphylactic-type rea… · thi…1132Injection site abscess · near1131Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Anaphylactic-type reaction

What the FDA AER plate says about Anaphylactic-type reaction

Signature read: 1,132 reports place Anaphylactic-type reaction in the upper third of FDA AER volume (#356 of 2,481). Report volume is upper-third scale: 1,132 named reports in the openFDA extract. 154 of 1,132 reports were death-coded (13.6% of named reports, not a population mortality rate). Nearest volume peer: Injection site abscess (±1 reports). Lead species Dog (826). Lead co-reported drug Moxidectin (193).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 826
Cattle 125
Horse 58
Human 48
Cat 47
Pig 20
Sheep 5
Alpaca 1
Donkey 1
Goat 1

Breeds Most Affected

Retriever - Labrador 87
Boxer (German Boxer) 57
Unknown 56
Chihuahua 53
Terrier - Bull - American Pit 50
Mixed (Cattle) 48
Crossbred Canine/dog 46
Retriever - Golden 32
Shepherd Dog - German 31
Dachshund (unspecified) 31

Associated Drugs

Moxidectin 193
Pyrantel Pamoate;Sarolaner 108
Melarsomine Dihydrochloride Injection 82
Maropitant Citrate 48
Milbemycin Oxime + Spinosad 45
Afoxolaner 41
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 38
Rabies Virus, 36
Cefovecin 35
Doramectin 31
Ivermectin + Pyrantel As Pamoate Salt 31
Melarsomine Dihydrochloride 29
Anti-Il31 Mab Mcs Lot #1283563 27
Fluralaner 13.64% 12-Week Chew 26
Lotilaner 22
Selamectin 20
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 20
Carprofen 20
Diphenhydramine 19
Prednisone 19

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Anaphylactic-type reaction, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (13.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Anaphylactic-type reaction (#356 of 2,481 by report volume); death-coded 13.6%. PlainBreed reaction plate · report volume stamp 1,132 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →