Reaction profile

The FDA adverse-event record for abdominal discomfort

777 FDA adverse-event reports reference abdominal discomfort (VeDDRA 2010). See the species, breeds, and drugs most associated with it below.

777
reports citing this reaction
14.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
777
Total Reports
116
Deaths
14.9%
Death Rate

Species Most Affected

Dog 633
Cat 82
Horse 43
Human 10
Cattle 9

Breeds Most Affected

Retriever - Labrador 69
Domestic Shorthair 52
Crossbred Canine/dog 51
Terrier - Yorkshire 28
Chihuahua 26
Boxer (German Boxer) 25
Shih Tzu 25
Shepherd Dog - German 19
Retriever - Golden 18
Dachshund (unspecified) 18

Associated Drugs

Milbemycin Oxime + Spinosad 148
Carprofen 66
Maropitant Citrate 63
Deracoxib 38
Trilostane 35
Spinosad 35
Gabapentin 30
Meloxicam 30
Oclacitinib Maleate 30
Fluralaner Chew Tablets 30
Tramadol 29
Afoxolaner 24
Moxidectin 22
Milbemycin Oxime + Praziquantel 22
Cyclosporine A 20
Famotidine 19
Ivermectin + Pyrantel As Pamoate Salt 19
Selamectin 18
Buprenorphine 18
Grapiprant 18

Abdominal discomfort Reaction Insights

777 reports name Abdominal discomfort; 116 recorded a death outcome (14.9% of reported events, not a population-level mortality rate). VeDDRA code: 2010.

By species: Dog (633 reports), Cat (82 reports), Horse (43 reports). By breed: Retriever - Labrador (69), Domestic Shorthair (52), Crossbred Canine/dog (51).

Most co-reported drugs: Milbemycin Oxime + Spinosad (148 reports), Carprofen (66 reports), Maropitant Citrate (63 reports), Deracoxib (38 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.