Reaction profile

The FDA adverse-event record for abdominal discomfort

825 FDA reports name abdominal discomfort, a high-volume reaction in the CVM extract (VeDDRA 2010). Plate stamps and neighbourhood peers follow.

#452 of 2,481
by report volume (all reactions)
825
reports citing this reaction
15.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Abdominal discomfort has 825 reports now versus 795 in that prior snapshot: 30 more (3.8%).

Report change
+30
Death-coded reports
+4
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Abdominal discomfort changes

FDA AER · VeDDRA plate

Code 2010 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 825 reports
  • DEATH-ELEV 15.2%
  • UPPER-Q #452/2481
  • PHOTO-FINISH Increased appetite
  • SPECIES-DOG Dog · 675
  • DRUG-LEAD Milbemycin Oxime… · 148
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Increased appetite (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Abdominal discomfort

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hepatomegaly · near827Squinting · near826Abdominal discomfort · this …825Increased appetite · near825Decreased bowel movem… · near821Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Abdominal discomfort

What the FDA AER plate says about Abdominal discomfort

Signature read: 125 death-coded reports is a heavy tail count for Abdominal discomfort in the CVM extract. Report volume is upper-third scale: 825 named reports in the openFDA extract. 125 of 825 reports were death-coded (15.2% of named reports, not a population mortality rate). Nearest volume peer: Increased appetite (±0 reports). Lead species Dog (675). Lead co-reported drug Milbemycin Oxime + Spinosad (148).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 675
Cat 87
Horse 43
Cattle 10
Human 10

Breeds Most Affected

Retriever - Labrador 73
Domestic Shorthair 56
Crossbred Canine/dog 55
Shih Tzu 29
Terrier - Yorkshire 28
Chihuahua 26
Boxer (German Boxer) 26
Shepherd Dog - German 23
Dachshund (unspecified) 20
Retriever - Golden 19

Associated Drugs

Milbemycin Oxime + Spinosad 148
Maropitant Citrate 79
Carprofen 70
Gabapentin 43
Deracoxib 39
Trilostane 37
Spinosad 35
Meloxicam 33
Oclacitinib Maleate 31
Afoxolaner 31
Tramadol 30
Fluralaner Chew Tablets 30
Grapiprant 23
Moxidectin 22
Famotidine 22
Milbemycin Oxime + Praziquantel 22
Cyclosporine A 20
Ivermectin + Pyrantel As Pamoate Salt 20
Buprenorphine 20
Bedinvetmab 20

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Abdominal discomfort, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (825 here).

Similar death-coded share

Nearest other reactions by death-coded share (15.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Abdominal discomfort (#452 of 2,481 by report volume); death-coded 15.2%. PlainBreed reaction plate · death-coded report count stamp 125 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →