INEFFECTIVE, ANTIINFLAMMATORY

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VeDDRA Code: 99086

1,055 adverse event reports referencing this reaction

1,055
Total Reports
90
Deaths
850.0%
Death Rate

Species Most Affected

Dog 793
Cat 183
Horse 34
Unknown 17
Cattle 17
Rabbit 3
Other Birds 2
Other Rodents 1
Goat 1
Rat 1

Breeds Most Affected

Retriever - Labrador 124
Dog (unknown) 98
Cat (unknown) 89
Domestic Shorthair 48
Crossbred Canine/dog 47
Shepherd Dog - German 46
Retriever - Golden 42
Unknown 23
Chihuahua 21
Beagle 20

Associated Drugs

Carprofen 314
Deracoxib 141
Grapiprant 140
Robenacoxib 115
Meloxicam 110
Methylprednisolone Acetate 106
Tramadol 66
Unknown Whether Concomitant Medications Other Than Anesthetic Protocol 59
Gabapentin 57
Firocoxib 52
Oclacitinib Maleate 46
Polysulfated Glycosaminoglycan 36
Prednisolone; Trimeprazine Tartrate 35
Cefovecin 25
Flunixin Meglumine Injectable 22
Prednisone 15
Selamectin 12
Maropitant Citrate 12
Methocarbamol 12
Doxycycline 11

Data Summary

Metric Value
Total reports referencing reaction 1,055
Reports with fatal outcome 90
Case-fatality rate (reported events) 850.0%
Species observed 10
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 99086.

INEFFECTIVE, ANTIINFLAMMATORY Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 1,055 adverse event reports that reference INEFFECTIVE, ANTIINFLAMMATORY as a reaction term, including 90 reports with a death outcome — a 850.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 99086, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

INEFFECTIVE, ANTIINFLAMMATORY appears most frequently in reports for Dog (793 reports), Cat (183 reports), Horse (34 reports) — with Dog dominating at 793 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (124), Dog (unknown) (98), Cat (unknown) (89). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with INEFFECTIVE, ANTIINFLAMMATORY are Carprofen (314 reports), Deracoxib (141 reports), Grapiprant (140 reports), Robenacoxib (115 reports), with Carprofen appearing alongside this reaction in 314 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial