Reaction profile

The FDA adverse-event record for ineffective, antiinflammatory

1,059 FDA reports name ineffective, antiinflammatory, a high-volume reaction in the CVM extract (VeDDRA 99086). Plate stamps and neighbourhood peers follow.

#376 of 2,481
by report volume (all reactions)
1,059
reports citing this reaction
8.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, ANTIINFLAMMATORY has 1,059 reports now versus 1,056 in that prior snapshot: 3 more (0.3%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, ANTIINFLAMMATORY changes

FDA AER · VeDDRA plate

Code 99086 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,059 reports
  • DEATH-PAR 8.5%
  • UPPER-Q #376/2481
  • PHOTO-FINISH CULTURE/TITER DATA AB…
  • SPECIES-DOG Dog · 796
  • DRUG-LEAD Carprofen · 314
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: CULTURE/TITER DATA ABNORMAL (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around INEFFECTIVE, ANTIINFLAMMATORY

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348CULTURE/TITER DATA AB… · near1061INEFFECTIVE, ANTIINFL… · thi…1059Corneal ulcer · near1054Elevated creatine-kin… · near1053Discoloured urine · near1051Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, ANTIINFLAMMATORY

What the FDA AER plate says about INEFFECTIVE, ANTIINFLAMMATORY

Signature read: 1,059 reports place INEFFECTIVE, ANTIINFLAMMATORY in the upper third of FDA AER volume (#376 of 2,481). Report volume is upper-third scale: 1,059 named reports in the openFDA extract. 90 of 1,059 reports were death-coded (8.5% of named reports, not a population mortality rate). Nearest volume peer: CULTURE/TITER DATA ABNORMAL (±2 reports). Lead species Dog (796). Lead co-reported drug Carprofen (314).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Carprofen appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 796
Cat 184
Horse 34
Unknown 17
Cattle 17
Rabbit 3
Other Birds 2
Other Rodents 1
Goat 1
Rat 1

Breeds Most Affected

Retriever - Labrador 124
Dog (unknown) 98
Cat (unknown) 90
Crossbred Canine/dog 48
Domestic Shorthair 48
Shepherd Dog - German 46
Retriever - Golden 42
Unknown 23
Chihuahua 21
Beagle 20

Associated Drugs

Carprofen 314
Grapiprant 143
Deracoxib 141
Robenacoxib 115
Meloxicam 110
Methylprednisolone Acetate 106
Tramadol 66
Unknown Whether Concomitant Medications Other Than Anesthetic Protocol 59
Gabapentin 57
Firocoxib 52
Oclacitinib Maleate 46
Polysulfated Glycosaminoglycan 37
Prednisolone; Trimeprazine Tartrate 35
Cefovecin 25
Flunixin Meglumine Injectable 22
Prednisone 15
Selamectin 12
Maropitant Citrate 12
Methocarbamol 12
Doxycycline 11

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, ANTIINFLAMMATORY, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (8.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, ANTIINFLAMMATORY (#376 of 2,481 by report volume); death-coded 8.5%. PlainBreed reaction plate · report volume stamp 1,059 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →