Reaction profile

The FDA adverse-event record for ineffective, antiinflammatory

1,055 FDA adverse-event reports reference ineffective, antiinflammatory (VeDDRA 99086). See the species, breeds, and drugs most associated with it below.

1,055
reports citing this reaction
8.5%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
1,055
Total Reports
90
Deaths
8.5%
Death Rate

Species Most Affected

Dog 793
Cat 183
Horse 34
Unknown 17
Cattle 17
Rabbit 3
Other Birds 2
Other Rodents 1
Goat 1
Rat 1

Breeds Most Affected

Retriever - Labrador 124
Dog (unknown) 98
Cat (unknown) 89
Domestic Shorthair 48
Crossbred Canine/dog 47
Shepherd Dog - German 46
Retriever - Golden 42
Unknown 23
Chihuahua 21
Beagle 20

Associated Drugs

Carprofen 314
Deracoxib 141
Grapiprant 140
Robenacoxib 115
Meloxicam 110
Methylprednisolone Acetate 106
Tramadol 66
Unknown Whether Concomitant Medications Other Than Anesthetic Protocol 59
Gabapentin 57
Firocoxib 52
Oclacitinib Maleate 46
Polysulfated Glycosaminoglycan 36
Prednisolone; Trimeprazine Tartrate 35
Cefovecin 25
Flunixin Meglumine Injectable 22
Prednisone 15
Selamectin 12
Maropitant Citrate 12
Methocarbamol 12
Doxycycline 11

INEFFECTIVE, ANTIINFLAMMATORY Reaction Insights

1,055 reports name INEFFECTIVE, ANTIINFLAMMATORY; 90 recorded a death outcome (8.5% of reported events, not a population-level mortality rate). VeDDRA code: 99086.

By species: Dog (793 reports), Cat (183 reports), Horse (34 reports). By breed: Retriever - Labrador (124), Dog (unknown) (98), Cat (unknown) (89).

Most co-reported drugs: Carprofen (314 reports), Deracoxib (141 reports), Grapiprant (140 reports), Robenacoxib (115 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.