Reaction profile

The FDA adverse-event record for underfilling, tubes

4,726 FDA adverse-event reports reference underfilling, tubes (VeDDRA 99031). See the species, breeds, and drugs most associated with it below.

4,726
reports citing this reaction
0.0%
death-coded share
Unknown
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
4,726
Total Reports
1
Deaths
0.0%
Death Rate

Species Most Affected

Unknown 4,624
Cat 50
Dog 45
Human 3
Guinea Pig 2
Ferret 1
Cattle 1

Breeds Most Affected

Unknown 4,630
Domestic Shorthair 18
Dog (unknown) 10
Domestic (unspecified) 9
Cat (unknown) 7
Terrier - Yorkshire 7
Chihuahua 5
Maltese 4
Domestic Longhair 4
Cat (other) 4

Associated Drugs

Selamectin 1,919
Imidacloprid + Moxidectin 787
Selamectin;Sarolaner 541
Fluralaner Spot-On Solution 371
Cyclosporin Ointment 330
Emodepside + Praziquantel 92
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 87
Cyclosporine 67
Buprenorphine 64
Milbemycin Oxime Solution 57
Mirtazapine 56
Milbemycin Oxime 55
Fluralaner/Moxidectin Spot-On 53
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 36
Ivermectin 27
Imidacloprid, Moxidectin 22
Eprinomectin + Esafoxolaner + Praziquantel 18
Fenbendazole 12
Ponazuril 9
Milbemycin 8

Underfilling, Tubes Reaction Insights

4,726 reports name Underfilling, Tubes; 1 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 99031.

By species: Unknown (4,624 reports), Cat (50 reports), Dog (45 reports). By breed: Unknown (4,630), Domestic Shorthair (18), Dog (unknown) (10).

Most co-reported drugs: Selamectin (1,919 reports), Imidacloprid + Moxidectin (787 reports), Selamectin;Sarolaner (541 reports), Fluralaner Spot-On Solution (371 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.