Reaction profile

The FDA adverse-event record for underfilling, tubes

4,808 FDA reports name underfilling, tubes, a high-volume reaction in the CVM extract (VeDDRA 99031). Plate stamps and neighbourhood peers follow.

#100 of 2,481
by report volume (all reactions)
4,808
reports citing this reaction
0.0%
death-coded share
Unknown
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Underfilling, Tubes has 4,808 reports now versus 4,775 in that prior snapshot: 33 more (0.7%).

Report change
+33
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Underfilling, Tubes changes

FDA AER · VeDDRA plate

Code 99031 VOL-MID

VOL-MID · DEATH-RARE · TOP-DECILE · PHOTO-FINISH · SPECIES-UNKNOWN · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 4,808 reports
  • DEATH-RARE 0.0%
  • TOP-DECILE #100/2481
  • PHOTO-FINISH Walking difficulty
  • SPECIES-UNKNOWN Unknown · 4,705
  • DRUG-LEAD Selamectin · 1,940
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Walking difficulty (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Underfilling, Tubes

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal ultrasound f… · near4860Deafness · near4836Appearance, Abnormal · near4824Underfilling, Tubes · this r…4808Walking difficulty · near4808Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Underfilling, Tubes

Underfilling, Tubes: low death-coded share in the FDA AER plate

Signature read: 4,808 reports place Underfilling, Tubes in the upper third of FDA AER volume (#100 of 2,481). Report volume is upper-third scale: 4,808 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 4,808 reports (0.0% of named reports). Nearest volume peer: Walking difficulty (±0 reports). Lead species Unknown (4,705). Lead co-reported drug Selamectin (1,940).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Selamectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 4,705
Cat 50
Dog 46
Human 3
Guinea Pig 2
Ferret 1
Cattle 1

Breeds Most Affected

Unknown 4,711
Domestic Shorthair 18
Dog (unknown) 11
Domestic (unspecified) 9
Cat (unknown) 7
Terrier - Yorkshire 7
Chihuahua 5
Maltese 4
Domestic Longhair 4
Cat (other) 4

Associated Drugs

Selamectin 1,940
Imidacloprid + Moxidectin 791
Selamectin;Sarolaner 576
Fluralaner Spot-On Solution 371
Cyclosporin Ointment 330
Emodepside + Praziquantel 94
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 88
Buprenorphine 72
Cyclosporine 67
Mirtazapine 64
Milbemycin Oxime Solution 57
Milbemycin Oxime 55
Fluralaner/Moxidectin Spot-On 55
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 36
Ivermectin 27
Imidacloprid, Moxidectin 22
Eprinomectin + Esafoxolaner + Praziquantel 18
Fenbendazole 12
Ponazuril 9
Milbemycin 8

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Underfilling, Tubes, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (4,808 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Underfilling, Tubes (#100 of 2,481 by report volume); death-coded 0.0%. PlainBreed reaction plate · report volume stamp 4,808 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →