Reaction profile

The FDA adverse-event record for cold feeling to the touch

131 FDA adverse-event reports reference cold feeling to the touch (VeDDRA 2741). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1258 of 2,481
by report volume (all reactions)
131
reports citing this reaction
38.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cold feeling to the touch has 131 reports now versus 126 in that prior snapshot: 5 more (4.0%).

Report change
+5
Death-coded reports
+0
Death-coded share
−1.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cold feeling to the touch changes

FDA AER · VeDDRA plate

Code 2741 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 131 reports
  • DEATH-HOT 38.2%
  • MID-PACK #1258/2481
  • PHOTO-FINISH Digestive tract hypom…
  • SPECIES-DOG Dog · 79
  • DRUG-LEAD Gabapentin · 15
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Digestive tract hypomotility (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Cold feeling to the touch

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site muco… · near132Cyanotic mucous membr… · near132Cold feeling to the t… · thi…131Digestive tract hypom… · near131Injection site hair c… · near131Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cold feeling to the touch

Cold feeling to the touch: high death-coded share in the FDA AER plate

Signature read: Cold feeling to the touch's 38.2% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 50 of 131 reports (38.2% of named reports). Nearest volume peer: Digestive tract hypomotility (±0 reports). Lead species Dog (79). Lead co-reported drug Gabapentin (15).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 79
Cat 47
Horse 2
Human 2
Cattle 1

Breeds Most Affected

Domestic Shorthair 27
Chihuahua 8
Pit Bull 6
Retriever - Labrador 6
Domestic Mediumhair 6
Shepherd Dog - German 5
Crossbred Canine/dog 4
Shepherd Dog - Australian 3
Cat (unknown) 3
Dog (unknown) 3

Associated Drugs

Gabapentin 15
Buprenorphine 14
Pyrantel Pamoate;Sarolaner 11
Maropitant Citrate 11
Afoxolaner 9
Fluralaner 13.64% 12-Week Chew 7
Fluid Therapy 7
Famotidine 7
Praziquantel + Pyrantel Pamoate 6
Ivermectin + Pyrantel As Pamoate Salt 6
Butorphanol 6
Isoflurane 6
Fluid Therapy (Unknown) 6
Maropitant 5
Mirtazapine 5
Bedinvetmab 5
Frunevetmab 5
Selamectin 4
Lotilaner 4
Robenacoxib 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Cold feeling to the touch, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (38.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cold feeling to the touch (#1258 of 2,481 by report volume); death-coded 38.2%. PlainBreed reaction plate · death-coded share stamp 38.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →