Reaction profile

The FDA adverse-event record for digestive tract hypomotility

126 FDA adverse-event reports reference digestive tract hypomotility (VeDDRA 2163). See the species, breeds, and drugs most associated with it below.

126
reports citing this reaction
24.6%
death-coded share
Dog
most-affected species
Maropitant
most-associated drug
Verify with FDA CVM →
126
Total Reports
31
Deaths
24.6%
Death Rate

Species Most Affected

Dog 92
Horse 18
Cat 13
Cattle 2
Donkey 1

Breeds Most Affected

Retriever - Labrador 11
Domestic (unspecified) 9
Chihuahua 6
Dog (unknown) 6
Retriever - Golden 6
Bulldog 5
Warmblood (unspecified) 4
Terrier - Yorkshire 3
Shepherd Dog - Australian 3
Quarter Horse 3

Associated Drugs

Maropitant 31
Maropitant Citrate 22
Carprofen 8
Metronidazole 7
Milbemycin Oxime + Spinosad 7
Firocoxib 6
Enrofloxacin 6
Moxidectin 5
Famotidine 5
Oclacitinib Maleate 4
Cephalexin 4
Fenbendazole 4
Buprenorphine 4
Metoclopramide 4
Milbemycin Oxime 4
Spinosad 3
Meloxicam 3
Detomidine 3
Amoxicillin 3
Dexamethasone Sodium Phosphate 3

Digestive tract hypomotility Reaction Insights

126 reports name Digestive tract hypomotility; 31 recorded a death outcome (24.6% of reported events, not a population-level mortality rate). VeDDRA code: 2163.

By species: Dog (92 reports), Horse (18 reports), Cat (13 reports). By breed: Retriever - Labrador (11), Domestic (unspecified) (9), Chihuahua (6).

Most co-reported drugs: Maropitant (31 reports), Maropitant Citrate (22 reports), Carprofen (8 reports), Metronidazole (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.