Lack of efficacy (neoplasia, partial remission)

Verify with FDA CVM →

VeDDRA Code: 2892

86 adverse event reports referencing this reaction

86
Total Reports
2
Deaths
230.0%
Death Rate

Species Most Affected

Dog 86

Breeds Most Affected

Retriever - Labrador 17
Terrier - Bull - American Pit 7
Dog (unknown) 6
Bulldog - French 6
Chihuahua 5
Pit Bull 5
Mountain Dog - Bernese 4
Boxer (German Boxer) 4
Terrier (unspecified) 4
Shepherd Dog - German 3

Associated Drugs

Prednisone 73
Diphenhydramine 69
Famotidine 68
Tigilanol Tiglate 59
Gabapentin 50
Butorphanol Tartrate 40
Dexmedetomidine Hydrochloride 32
Atipamezole Hydrochloride 28
Maropitant Citrate 23
Butorphanol 17
Trazodone 12
Propofol 11
Buprenorphine 10
Dexmedetomidine 10
Oclacitinib Maleate 7
Midazolam 7
Isoflurane 6
Dexamethasone 6
Alfaxalone 6
Prednisolone 6

Data Summary

Metric Value
Total reports referencing reaction 86
Reports with fatal outcome 2
Case-fatality rate (reported events) 230.0%
Species observed 1
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2892.

Lack of efficacy (neoplasia, partial remission) Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 86 adverse event reports that reference Lack of efficacy (neoplasia, partial remission) as a reaction term, including 2 reports with a death outcome — a 230.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2892, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Lack of efficacy (neoplasia, partial remission) appears most frequently in reports for Dog (86 reports) — with Dog dominating at 86 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (17), Terrier - Bull - American Pit (7), Dog (unknown) (6). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Lack of efficacy (neoplasia, partial remission) are Prednisone (73 reports), Diphenhydramine (69 reports), Famotidine (68 reports), Tigilanol Tiglate (59 reports), with Prednisone appearing alongside this reaction in 73 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial