Reaction profile

The FDA adverse-event record for demodicosis

228 FDA adverse-event reports reference demodicosis (VeDDRA 2587). See the species, breeds, and drugs most associated with it below.

228
reports citing this reaction
2.2%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
228
Total Reports
5
Deaths
2.2%
Death Rate

Species Most Affected

Dog 225
Cat 3

Breeds Most Affected

Dog (unknown) 27
Retriever - Labrador 22
Shih Tzu 16
Bulldog 12
Pit Bull 11
Shepherd Dog - German 10
Terrier - Bull - American Pit 10
Crossbred Canine/dog 9
Terrier - Yorkshire 8
Chihuahua 8

Associated Drugs

Oclacitinib Maleate 129
Milbemycin Oxime + Spinosad 75
Anti-Il31 Mab Mcs Lot #1283563 21
Lotilaner 12
Milbemycin Oxime + Praziquantel 9
Ivermectin 8
Cephalexin 8
Fluralaner 7
Cefovecin 7
Trilostane 7
Afoxolaner 6
Prednisolone; Trimeprazine Tartrate 6
Diphenhydramine Hcl 5
Selamectin 5
Milbemycin Oxime 4
Immunotherapy 4
Antibiotic 4
Spinosad 4
Prednisone 4
Cefpodoxime Proxetil 3

Demodicosis Reaction Insights

228 reports name Demodicosis; 5 recorded a death outcome (2.2% of reported events, not a population-level mortality rate). VeDDRA code: 2587.

By species: Dog (225 reports), Cat (3 reports). By breed: Dog (unknown) (27), Retriever - Labrador (22), Shih Tzu (16).

Most co-reported drugs: Oclacitinib Maleate (129 reports), Milbemycin Oxime + Spinosad (75 reports), Anti-Il31 Mab Mcs Lot #1283563 (21 reports), Lotilaner (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.