Reaction profile

The FDA adverse-event record for application site hair loss

7,798 FDA adverse-event reports reference application site hair loss (VeDDRA 3). See the species, breeds, and drugs most associated with it below.

7,798
reports citing this reaction
0.6%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
7,798
Total Reports
47
Deaths
0.6%
Death Rate

Species Most Affected

Cat 7,490
Dog 278
Cattle 21
Horse 3
Rabbit 2
Human 2
Bobcat 1
Lynx 1

Breeds Most Affected

Domestic Shorthair 5,129
Domestic Longhair 503
Domestic Mediumhair 451
Cat (other) 378
Cat (unknown) 214
Siamese 157
Maine Coon 135
Bengal 83
Russian 58
Crossbred Feline/cat 55

Associated Drugs

Selamectin 2,240
Selamectin;Sarolaner 2,135
Fluralaner Spot-On Solution 1,843
Fluralaner/Moxidectin Spot-On 603
Eprinomectin + Esafoxolaner + Praziquantel 232
Emodepside + Praziquantel 193
Imidacloprid + Moxidectin 179
Buprenorphine 167
Cefovecin 57
Ivermectin + Pyrantel As Pamoate Salt 50
Isoflurane 45
Robenacoxib 38
Maropitant Citrate 36
Propofol 35
Methylprednisolone Acetate 34
Spinetoram 32
Fipronil 10%/S Methoprene 9% Spot On 32
Eprinomectin + Praziquantel 29
Imidacloprid, Flumethrin 29
Dexmedetomidine 29

Application site hair loss Reaction Insights

7,798 reports name Application site hair loss; 47 recorded a death outcome (0.6% of reported events, not a population-level mortality rate). VeDDRA code: 3.

By species: Cat (7,490 reports), Dog (278 reports), Cattle (21 reports). By breed: Domestic Shorthair (5,129), Domestic Longhair (503), Domestic Mediumhair (451).

Most co-reported drugs: Selamectin (2,240 reports), Selamectin;Sarolaner (2,135 reports), Fluralaner Spot-On Solution (1,843 reports), Fluralaner/Moxidectin Spot-On (603 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.