Reaction profile

The FDA adverse-event record for solution, abnormal

2,181 FDA reports name solution, abnormal, a high-volume reaction in the CVM extract (VeDDRA 99023). Plate stamps and neighbourhood peers follow.

#216 of 2,481
by report volume (all reactions)
2,181
reports citing this reaction
0.6%
death-coded share
Unknown
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Solution, Abnormal has 2,181 reports now versus 2,153 in that prior snapshot: 28 more (1.3%).

Report change
+28
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Solution, Abnormal changes

FDA AER · VeDDRA plate

Code 99023 VOL-MID

VOL-MID · DEATH-RARE · TOP-DECILE · PHOTO-FINISH · SPECIES-UNKNOWN · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,181 reports
  • DEATH-RARE 0.6%
  • TOP-DECILE #216/2481
  • PHOTO-FINISH Injection site lump
  • SPECIES-UNKNOWN Unknown · 2,045
  • DRUG-LEAD Enrofloxacin · 417
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Injection site lump (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Solution, Abnormal

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Ear infection NOS · near2187Lack of efficacy (ect… · near2183Injection site lump · near2181Solution, Abnormal · this re…2181Inappropriate defecat… · near2169Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Solution, Abnormal

Solution, Abnormal: low death-coded share in the FDA AER plate

Signature read: 2,181 reports place Solution, Abnormal in the upper third of FDA AER volume (#216 of 2,481). Report volume is upper-third scale: 2,181 named reports in the openFDA extract. Death-coded share is lower-third: 13 of 2,181 reports (0.6% of named reports). Nearest volume peer: Injection site lump (±0 reports). Lead species Unknown (2,045). Lead co-reported drug Enrofloxacin (417).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Enrofloxacin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 2,045
Dog 55
Cat 44
Cattle 20
Human 7
Horse 5
Other 2
Rabbit 1
Pig 1
Goat 1

Breeds Most Affected

Unknown 2,057
Domestic Shorthair 18
Cattle (unknown) 9
Crossbred Canine/dog 8
Dog (unknown) 7
Domestic (unspecified) 6
Domestic Longhair 5
Cat (other) 5
Holstein-Friesian also known as Holstein 4
Retriever - Golden 4

Associated Drugs

Enrofloxacin 417
Cefovecin 185
Cyclosporine 138
Ceftiofur Sodium 132
Moxidectin 113
Selamectin 99
Furosemide 97
Meloxicam 55
Carprofen 54
Methylprednisolone Acetate 47
Imidacloprid + Moxidectin 46
Cefovecin Sodium 43
Praziquantel 37
Maropitant Citrate 31
Doramectin 28
Propofol 23
Ceftiofur 23
Flunixin Meglumine 21
Tiletamine, Zolazepam 19
Ketamine Hydrochloride 18

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Solution, Abnormal, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (0.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Solution, Abnormal (#216 of 2,481 by report volume); death-coded 0.6%. PlainBreed reaction plate · report volume stamp 2,181 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →