Reaction profile

The FDA adverse-event record for solution, abnormal

2,119 FDA adverse-event reports reference solution, abnormal (VeDDRA 99023). See the species, breeds, and drugs most associated with it below.

2,119
reports citing this reaction
0.6%
death-coded share
Unknown
most-affected species
Enrofloxacin
most-associated drug
Verify with FDA CVM →
2,119
Total Reports
13
Deaths
0.6%
Death Rate

Species Most Affected

Unknown 1,983
Dog 55
Cat 44
Cattle 20
Human 7
Horse 5
Other 2
Rabbit 1
Pig 1
Goat 1

Breeds Most Affected

Unknown 1,995
Domestic Shorthair 18
Cattle (unknown) 9
Crossbred Canine/dog 8
Dog (unknown) 7
Domestic (unspecified) 6
Domestic Longhair 5
Cat (other) 5
Holstein-Friesian also known as Holstein 4
Retriever - Golden 4

Associated Drugs

Enrofloxacin 417
Cefovecin 180
Cyclosporine 138
Ceftiofur Sodium 127
Moxidectin 104
Selamectin 99
Furosemide 97
Meloxicam 55
Carprofen 50
Methylprednisolone Acetate 47
Cefovecin Sodium 43
Imidacloprid + Moxidectin 43
Praziquantel 37
Maropitant Citrate 30
Doramectin 28
Ceftiofur 23
Flunixin Meglumine 19
Tiletamine, Zolazepam 19
Ketamine Hydrochloride 18
Polysulfated Glycosaminoglycan 18

Solution, Abnormal Reaction Insights

2,119 reports name Solution, Abnormal; 13 recorded a death outcome (0.6% of reported events, not a population-level mortality rate). VeDDRA code: 99023.

By species: Unknown (1,983 reports), Dog (55 reports), Cat (44 reports). By breed: Unknown (1,995), Domestic Shorthair (18), Cattle (unknown) (9).

Most co-reported drugs: Enrofloxacin (417 reports), Cefovecin (180 reports), Cyclosporine (138 reports), Ceftiofur Sodium (127 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.