Reaction profile

The FDA adverse-event record for lack of efficacy (endoparasite) - tapeworm

8,280 FDA reports name lack of efficacy (endoparasite) - tapeworm, a high-volume reaction in the CVM extract (VeDDRA 2657). Plate stamps and neighbourhood peers follow.

#56 of 2,481
by report volume (all reactions)
8,280
reports citing this reaction
0.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (endoparasite) - tapeworm has 8,280 reports now versus 8,024 in that prior snapshot: 256 more (3.2%).

Report change
+256
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (endoparasite) - tapeworm changes

FDA AER · VeDDRA plate

Code 2657 VOL-HIGH

VOL-HIGH · DEATH-RARE · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 8,280 reports
  • DEATH-RARE 0.4%
  • TOP-DECILE #56/2481
  • PHOTO-FINISH Lack of efficacy (fle…
  • SPECIES-DOG Dog · 6,852
  • DRUG-LEAD Pyrantel Pamoate;… · 2,131
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Lack of efficacy (flea) (±40 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lack of efficacy - tapeworm

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Product Defect, Gener… · near8459Hives (see also 'Skin… · near8336Lack of efficacy (fle… · near8320Lack of efficacy (end… · thi…8280Application site hair… · near8127Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of efficacy (endoparasite) - tapeworm

Lack of efficacy (endoparasite) - tapeworm: low death-coded share in the FDA AER plate

Signature read: 8,280 reports place Lack of efficacy (endoparasite) - tapeworm in the upper third of FDA AER volume (#56 of 2,481). Report volume is upper-third scale: 8,280 named reports in the openFDA extract. Death-coded share is lower-third: 32 of 8,280 reports (0.4% of named reports). Nearest volume peer: Lack of efficacy (flea) (±40 reports). Lead species Dog (6,852). Lead co-reported drug Pyrantel Pamoate;Sarolaner (2,131).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Pyrantel Pamoate;Sarolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 6,852
Cat 1,370
Cattle 24
Horse 11
Sheep 11
Chicken 3
Goat 2
Other 2
Buffalo 1
Cougar 1

Breeds Most Affected

Retriever - Labrador 1,034
Domestic Shorthair 807
Retriever - Golden 511
Crossbred Canine/dog 506
Dog (unknown) 457
Shepherd Dog - German 340
Cat (unknown) 280
Shepherd Dog - Australian 237
Chihuahua 152
Beagle 149

Associated Drugs

Pyrantel Pamoate;Sarolaner 2,131
Moxidectin 946
Praziquantel 618
Milbemycin Oxime + Praziquantel 588
Ivermectin + Pyrantel As Pamoate Salt 531
Emodepside + Praziquantel 395
Afoxolaner 332
Milbemycin Oxime + Spinosad 315
Febantel + Praziquantel + Pyrantel Pamoate 315
Selamectin 260
Milbemcyin Oxime, Lufenuron, Praziquantel 225
Selamectin;Sarolaner 224
Milbemycin/Lufenuron/Pzq Chew 176
Epsiprantel 157
Lotilaner 157
Eprinomectin + Esafoxolaner + Praziquantel 155
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 139
Sarolaner 137
Fenbendazole 136
Fluralaner 13.64% 12-Week Chew 118

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lack of efficacy (endoparasite) - tapeworm, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (endoparasite) - tapeworm (#56 of 2,481 by report volume); death-coded 0.4%. PlainBreed reaction plate · report volume stamp 8,280 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →