Reaction profile

The FDA adverse-event record for lack of efficacy (endoparasite) - tapeworm

7,662 FDA adverse-event reports reference lack of efficacy (endoparasite) - tapeworm (VeDDRA 2657). See the species, breeds, and drugs most associated with it below.

7,662
reports citing this reaction
0.4%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
7,662
Total Reports
30
Deaths
0.4%
Death Rate

Species Most Affected

Dog 6,322
Cat 1,285
Cattle 22
Sheep 11
Horse 10
Goat 2
Other 2
Chicken 2
Buffalo 1
Cougar 1

Breeds Most Affected

Retriever - Labrador 959
Domestic Shorthair 744
Crossbred Canine/dog 472
Retriever - Golden 461
Dog (unknown) 433
Shepherd Dog - German 320
Cat (unknown) 269
Shepherd Dog - Australian 223
Chihuahua 143
Beagle 138

Associated Drugs

Pyrantel Pamoate;Sarolaner 1,937
Moxidectin 855
Praziquantel 592
Milbemycin Oxime + Praziquantel 571
Ivermectin + Pyrantel As Pamoate Salt 510
Emodepside + Praziquantel 384
Milbemycin Oxime + Spinosad 312
Afoxolaner 306
Febantel + Praziquantel + Pyrantel Pamoate 295
Selamectin 258
Milbemcyin Oxime, Lufenuron, Praziquantel 225
Selamectin;Sarolaner 203
Milbemycin/Lufenuron/Pzq Chew 162
Epsiprantel 149
Lotilaner 147
Fenbendazole 129
Eprinomectin + Esafoxolaner + Praziquantel 127
Sarolaner 123
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 103
Fluralaner 13.64% 12-Week Chew 99

Lack of efficacy (endoparasite) - tapeworm Reaction Insights

7,662 reports name Lack of efficacy (endoparasite) - tapeworm; 30 recorded a death outcome (0.4% of reported events, not a population-level mortality rate). VeDDRA code: 2657.

By species: Dog (6,322 reports), Cat (1,285 reports), Cattle (22 reports). By breed: Retriever - Labrador (959), Domestic Shorthair (744), Crossbred Canine/dog (472).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (1,937 reports), Moxidectin (855 reports), Praziquantel (592 reports), Milbemycin Oxime + Praziquantel (571 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.