Reaction profile

The FDA adverse-event record for pinnal reddening

632 FDA adverse-event reports reference pinnal reddening (VeDDRA 360). See the species, breeds, and drugs most associated with it below.

632
reports citing this reaction
1.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
632
Total Reports
9
Deaths
1.4%
Death Rate

Species Most Affected

Dog 579
Cat 51
Cattle 1
Human 1

Breeds Most Affected

Retriever - Labrador 75
Crossbred Canine/dog 46
Retriever - Golden 38
Domestic Shorthair 33
Shepherd Dog - German 23
Chihuahua 19
Dog (unknown) 17
Shih Tzu 16
Boxer (German Boxer) 16
Beagle 15

Associated Drugs

Milbemycin Oxime + Spinosad 227
Afoxolaner 70
Moxidectin 33
Ivermectin + Pyrantel As Pamoate Salt 24
Spinosad 19
Genta/Momet/Clotrim Ear Oint 18
Selamectin 16
Maropitant Citrate 16
Betamethasone + Florfenicol + Terbinafine 16
Prednisone 15
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 15
Carprofen 14
Fluralaner Chew Tablets 13
Oclacitinib Maleate 13
Pyrantel Pamoate;Sarolaner 13
Tresaderm Dermatological Solution 12
Orbiflox/Momet/Posaco Eardrops 11
Rabies Vaccine 10
Milbemycin Oxime + Praziquantel 10
Dexamethasone + Neomycin Sulfate + Thiabendazole 10

Pinnal reddening Reaction Insights

632 reports name Pinnal reddening; 9 recorded a death outcome (1.4% of reported events, not a population-level mortality rate). VeDDRA code: 360.

By species: Dog (579 reports), Cat (51 reports), Cattle (1 reports). By breed: Retriever - Labrador (75), Crossbred Canine/dog (46), Retriever - Golden (38).

Most co-reported drugs: Milbemycin Oxime + Spinosad (227 reports), Afoxolaner (70 reports), Moxidectin (33 reports), Ivermectin + Pyrantel As Pamoate Salt (24 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.