Reaction profile

The FDA adverse-event record for unconscious

296 FDA adverse-event reports reference unconscious (VeDDRA 1857). See the species, breeds, and drugs most associated with it below.

296
reports citing this reaction
31.1%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
296
Total Reports
92
Deaths
31.1%
Death Rate

Species Most Affected

Dog 237
Cat 39
Human 9
Horse 4
Cattle 2
Pig 2
Fox 1
Ferret 1
Other Mammals 1

Breeds Most Affected

Retriever - Labrador 30
Domestic Shorthair 17
Chihuahua 15
Retriever - Golden 15
Unknown 12
Crossbred Canine/dog 12
Terrier (unspecified) 10
Shepherd Dog - Australian 10
Shepherd Dog - German 10
Dog (unknown) 9

Associated Drugs

Afoxolaner 39
Milbemycin Oxime + Spinosad 27
Fluralaner Chew Tablets 23
Ivermectin + Pyrantel As Pamoate Salt 22
Buprenorphine 12
Moxidectin 12
Propofol 12
Isoflurane 11
Bedinvetmab 11
Cefovecin 10
Butorphanol 10
Spinosad 9
Maropitant Citrate 9
Enrofloxacin 9
Gabapentin 9
Fluralaner 13.64% 12-Week Chew 9
Pyrantel Pamoate;Sarolaner 9
Milbemycin Oxime + Praziquantel 8
Frunevetmab 8
Prednisone 6

Unconscious Reaction Insights

296 reports name Unconscious; 92 recorded a death outcome (31.1% of reported events, not a population-level mortality rate). VeDDRA code: 1857.

By species: Dog (237 reports), Cat (39 reports), Human (9 reports). By breed: Retriever - Labrador (30), Domestic Shorthair (17), Chihuahua (15).

Most co-reported drugs: Afoxolaner (39 reports), Milbemycin Oxime + Spinosad (27 reports), Fluralaner Chew Tablets (23 reports), Ivermectin + Pyrantel As Pamoate Salt (22 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.