Reaction profile

The FDA adverse-event record for unconscious

311 FDA adverse-event reports reference unconscious (VeDDRA 1857). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#852 of 2,481
by report volume (all reactions)
311
reports citing this reaction
31.5%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Unconscious has 311 reports now versus 307 in that prior snapshot: 4 more (1.3%).

Report change
+4
Death-coded reports
+1
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Unconscious changes

FDA AER · VeDDRA plate

Code 1857 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 311 reports
  • DEATH-HOT 31.5%
  • MID-PACK #852/2481
  • PHOTO-FINISH Elevated haematocrit
  • SPECIES-DOG Dog · 251
  • DRUG-LEAD Afoxolaner · 41
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated haematocrit (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Unconscious

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Addison's disease · near312Elevated haematocrit · near311Liver tumour · near311Swollen feet · near311Unconscious · this reaction311Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Unconscious

Unconscious: high death-coded share in the FDA AER plate

Signature read: 98 death-coded reports is a heavy tail count for Unconscious in the CVM extract. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 98 of 311 reports (31.5% of named reports). Nearest volume peer: Elevated haematocrit (±0 reports). Lead species Dog (251). Lead co-reported drug Afoxolaner (41).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 251
Cat 39
Human 9
Horse 4
Cattle 2
Pig 2
Fox 1
Ferret 1
Other Mammals 1
Rat 1

Breeds Most Affected

Retriever - Labrador 30
Domestic Shorthair 17
Chihuahua 15
Retriever - Golden 15
Crossbred Canine/dog 14
Unknown 13
Terrier (unspecified) 10
Shepherd Dog - Australian 10
Shepherd Dog - German 10
Dog (unknown) 9

Associated Drugs

Afoxolaner 41
Milbemycin Oxime + Spinosad 28
Fluralaner Chew Tablets 23
Ivermectin + Pyrantel As Pamoate Salt 22
Bedinvetmab 15
Moxidectin 13
Isoflurane 12
Buprenorphine 12
Propofol 12
Cefovecin 10
Butorphanol 10
Gabapentin 10
Spinosad 9
Maropitant Citrate 9
Enrofloxacin 9
Fluralaner 13.64% 12-Week Chew 9
Pyrantel Pamoate;Sarolaner 9
Milbemycin Oxime + Praziquantel 8
Frunevetmab 8
Prednisone 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Unconscious, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (311 here).

Similar death-coded share

Nearest other reactions by death-coded share (31.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Unconscious (#852 of 2,481 by report volume); death-coded 31.5%. PlainBreed reaction plate · death-coded report count stamp 98 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →