Increased heart rate
VeDDRA Code: 193
1,577 adverse event reports referencing this reaction
1,577
Total Reports
236
Deaths
1500.0%
Death Rate
Species Most Affected
Dog 1,125
Cat 334
Human 57
Horse 49
Cattle 5
Goat 1
Pig 1
Mule 1
Other Equids 1
Guinea Pig 1
Breeds Most Affected
Domestic Shorthair 191
Retriever - Labrador 111
Crossbred Canine/dog 75
Unknown 64
Terrier - Yorkshire 57
Chihuahua 57
Shih Tzu 50
Domestic Longhair 42
Shepherd Dog - German 39
Retriever - Golden 38
Associated Drugs
Milbemycin Oxime + Spinosad 229
Nitenpyram 156
Moxidectin 73
Maropitant Citrate 67
Pimobendan 66
Spinosad 65
Milbemycin Oxime + Praziquantel 64
Buprenorphine 63
Afoxolaner 50
Gabapentin 48
Carprofen 47
Isoflurane 43
Pyrantel Pamoate;Sarolaner 41
Sarolaner 38
Propofol 38
Prednisone 36
Diphenhydramine 35
Bedinvetmab 34
Fluralaner Chew Tablets 32
Lotilaner 32
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.