Ivermectin + Pyrantel
8,038 adverse event reports submitted to the FDA
Active Ingredients
Administration Routes
Species Affected
Most Affected Breeds
Most Reported Reactions
Outcome Breakdown
Data Summary
| Metric | Value |
|---|---|
| Total adverse event reports | 8,038 |
| Reports involving death | 134 |
| Case-fatality rate (reported events) | 170.0% |
| Distinct species in reports | 4 |
| Distinct breeds in reports | 20 |
| Distinct reactions reported | 20 |
| Active ingredients on file | 3 |
Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER). Counts reflect voluntary reports only.
Ivermectin + Pyrantel Adverse Event Insights
The FDA Center for Veterinary Medicine database currently holds 8,038 adverse event reports referencing Ivermectin + Pyrantel, including 134 reports in which the animal died — a 170.0% case-fatality figure among reported events only, not a population-level mortality rate. Active ingredients on file: Ivermectin, Ivermectin + Pyrantel, Pyrantel. Reported administration routes include Oral, Unknown, Intrathoracic, Unassigned. These numbers reflect voluntary submissions from pet owners, veterinarians, and manufacturers and therefore under-represent mild events and over-represent severe ones — a pattern the FDA has documented repeatedly for pharmacovigilance datasets.
The species most frequently named in Ivermectin + Pyrantel reports are Dog (7,638 reports), Unknown (391 reports), Cat (8 reports), with Dog accounting for the largest share. Within those species, Crossbred Canine/dog (1,308), Retriever - Labrador (866), Unknown (838) appear most often — though breed popularity and ownership density shape these counts as much as any drug-specific sensitivity. This distribution matters because the same active ingredient can behave very differently across body sizes, ages, and species physiology.
The most commonly reported clinical signs associated with Ivermectin + Pyrantel are Lack of efficacy (endoparasite) - heartworm (2,155), Vomiting (1,217), INEFFECTIVE, HEARTWORM LARVAE (954), Lack of efficacy (endoparasite) - hookworm (604). Of the 7,645 reports with a coded outcome, Ongoing is the leading category at 50.8%. Because FDA adverse event data describes correlation rather than causation, these figures are best used to frame informed questions with a veterinarian and to compare reporting patterns across related products — not as a standalone safety verdict on Ivermectin + Pyrantel.
Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates
Read our methodology — how this data is sourced, computed, and verified.