Ivermectin + Pyrantel
8,038 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
8,038
Total Reports
134
Deaths Reported
170.0%
Death Rate
Active Ingredients
IvermectinIvermectin + PyrantelPyrantel
Administration Routes
OralUnknownIntrathoracicUnassigned
Species Affected
Dog 7,638
Unknown 391
Cat 8
Human 1
Most Affected Breeds
Crossbred Canine/dog 1,308
Retriever - Labrador 866
Unknown 838
Shepherd Dog - German 391
Dog (unknown) 310
Pit Bull 262
Chihuahua 254
Retriever - Golden 253
Beagle 186
Boxer (German Boxer) 169
Most Reported Reactions
Lack of efficacy (endoparasite) - heartworm 2,155
Vomiting 1,217
INEFFECTIVE, HEARTWORM LARVAE 954
Lack of efficacy (endoparasite) - hookworm 604
Diarrhoea 504
UNPALATABLE 492
Lethargy (see also Central nervous system depression in 'Neurological') 420
Emesis (multiple) 330
INEFFECTIVE, HOOKS 310
Lack of efficacy (endoparasite) - roundworm NOS 228
Product Defect, General 219
Product problem 184
Outcome Breakdown
Ongoing
3,886 (50.8%)
Recovered/Normal
2,084 (27.3%)
Outcome Unknown
1,443 (18.9%)
Recovered with Sequela
98 (1.3%)
Euthanized
68 (0.9%)
Died
66 (0.9%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.