Lufenuron + Milbemycin Oxime

8,207 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

8,207

Total Reports

154

Deaths Reported

190.0%

Death Rate

Active Ingredients

LufenuronMilbemycin Oxime

Administration Routes

OralUnknownTopicalOphthalmicOther

Species Affected

Dog 7,760

Unknown 410

Human 22

Cat 11

Wolf 2

Quail 1

Other Canids 1

Most Affected Breeds

Retriever - Labrador 1,156

Unknown 441

Shepherd Dog - German 439

Retriever - Golden 389

Crossbred Canine/dog 385

Chihuahua 248

Beagle 235

Dog (unknown) 232

Terrier - Yorkshire 213

Shih Tzu 206

Most Reported Reactions

INEFFECTIVE, HEARTWORM LARVAE 1,253

Lack of efficacy - NOS 962

INEFFECTIVE, HOOKS 879

Diarrhoea 715

Vomiting 701

Lethargy (see also Central nervous system depression in 'Neurological') 697

Lack of efficacy (endoparasite) - heartworm 615

Emesis 597

Lack of efficacy (endoparasite) - hookworm 504

INEFFECTIVE, ASCARIDS NOS 349

Lack of efficacy (heartworm) 338

Lack of efficacy (endoparasite) - whipworm 239

Outcome Breakdown

Outcome Unknown

3,296 (42.3%)

Recovered/Normal

2,821 (36.2%)

Ongoing

1,488 (19.1%)

Died

78 (1.0%)

Euthanized

76 (1.0%)

Recovered with Sequela

26 (0.3%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.