Pyrantel Pamoate;Sarolaner

47,313 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

47,313

Total Reports

826

Deaths Reported

170.0%

Death Rate

Active Ingredients

Pyrantel Pamoate;Sarolaner

Administration Routes

OralUnknownSubcutaneousTopicalOphthalmicOtherRespiratory (Inhalation)EndotrachealIntrauterineIntradermal

Species Affected

Dog 45,845

Unknown 1,399

Cat 42

Human 24

Other Canids 2

Marsupial 1

Most Affected Breeds

Retriever - Labrador 5,436

Retriever - Golden 3,915

Dog (unknown) 3,189

Crossbred Canine/dog 2,348

Shepherd Dog - German 1,986

Terrier - Bull - American Pit 1,554

Shepherd Dog - Australian 1,517

Unknown 1,426

Chihuahua 1,400

Shih Tzu 1,141

Most Reported Reactions

Vomiting 8,460

Lack of efficacy (bacteria) - Borrelia 5,354

Lack of efficacy (endoparasite) - heartworm 4,843

Seizure NOS 3,838

Lack of efficacy (endoparasite) - hookworm 3,730

Diarrhoea 3,596

Lack of efficacy (endoparasite) - roundworm NOS 2,864

Lack of efficacy (ectoparasite) - tick NOS 2,765

Lethargy (see also Central nervous system depression in 'Neurological') 1,983

Lack of efficacy (endoparasite) - tapeworm 1,937

Lack of efficacy (ectoparasite) - flea 1,546

Lack of efficacy (bacteria) - Anaplasma 1,296

Outcome Breakdown

Ongoing

27,485 (59.8%)

Recovered/Normal

8,941 (19.5%)

Outcome Unknown

8,671 (18.9%)

Died

445 (1.0%)

Euthanized

381 (0.8%)

Recovered with Sequela

10 (0.0%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.