Drug profile

The FDA adverse-event record for Betamethasone + Florfenicol + Terbinafine

2,221 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Betamethasone + Florfenicol + Terbinafine. See the species affected, top reactions, and outcomes below.

2,221
adverse-event reports
1.7%
death-coded share
Dog
most-reported species
1,128
Lack of efficacy - NOS - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
2,221
Total Reports
38
Deaths Reported
1.7%
Death Rate

Active Ingredients

BetamethasoneFlorfenicolTerbinafine

Administration Routes

Auricular (Otic)UnknownTopicalOralIntraocularOphthalmicCutaneousOther

Species Affected

Dog 1,955
Cat 136
Unknown 115
Human 14
Other Cervids 1

Most Affected Breeds

Retriever - Labrador 296
Dog (unknown) 198
Unknown 132
Spaniel - Cocker American 110
Retriever - Golden 109
Domestic Shorthair 82
Shih Tzu 80
Shepherd Dog - German 71
Chihuahua 62
Terrier - Yorkshire 54

Most Reported Reactions

Lack of efficacy - NOS 1,128
Ear discharge 159
Loss of hearing 112
Vomiting 100
Lethargy (see also Central nervous system depression in 'Neurological') 91
Head shake - ear disorder 88
CULTURE/TITER DATA ABNORMAL 82
Deafness 80
Ear pain 75
Hearing decreased 75
Behavioural disorder NOS 73
Other abnormal test result NOS 71

Outcome Breakdown

Outcome Unknown
1,269 (60.3%)
Ongoing
484 (23.0%)
Recovered/Normal
261 (12.4%)
Recovered with Sequela
54 (2.6%)
Euthanized
21 (1.0%)
Died
17 (0.8%)

Betamethasone + Florfenicol + Terbinafine Adverse Event Insights

2,221 reports name Betamethasone + Florfenicol + Terbinafine; 38 recorded a death outcome (1.7% of reported events, not a population-level mortality rate). Active ingredients: Betamethasone, Florfenicol, Terbinafine. Administration routes: Auricular (Otic), Unknown, Topical, Oral.

By species: Dog (1,955 reports), Cat (136 reports), Unknown (115 reports). By breed: Retriever - Labrador (296), Dog (unknown) (198), Unknown (132).

Leading clinical signs: Lack of efficacy - NOS (1,128), Ear discharge (159), Loss of hearing (112), Vomiting (100). Outcome, 2,106 coded reports: Outcome Unknown leads at 60.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.