Buprenorphine

6,797 adverse event reports submitted to the FDA

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

6,797

Total Reports

1,021

Deaths Reported

1500.0%

Death Rate

Active Ingredients

Buprenorphine

Administration Routes

TopicalUnknownSubcutaneousIntramuscularTransdermalOralIntravenousParenteralOtherSublingual

Species Affected

Cat 5,265

Dog 1,267

Unknown 149

Human 58

Rabbit 27

Mouse 13

Rat 6

Guinea Pig 4

Horse 2

Ferret 2

Most Affected Breeds

Domestic Shorthair 2,770

Cat (unknown) 1,033

Domestic Longhair 377

Domestic Mediumhair 276

Unknown 231

Cat (other) 180

Siamese 157

Retriever - Labrador 125

Maine Coon 89

Ragdoll 72

Most Reported Reactions

Behavioural disorder NOS 984

Not eating 748

Dilated pupils 731

Anorexia 591

Lethargy (see also Central nervous system depression in 'Neurological') 586

Hyperactivity 568

Death 545

Dysphoria 519

Vomiting 445

Death by euthanasia 418

Fever 393

Not sleeping 361

Outcome Breakdown

Ongoing

2,065 (30.9%)

Recovered/Normal

1,963 (29.4%)

Outcome Unknown

1,604 (24.0%)

Died

601 (9.0%)

Euthanized

427 (6.4%)

Recovered with Sequela

15 (0.2%)

Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.