Cyphenothrin + Fipronil
109 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
109
Total Reports
3
Deaths Reported
280.0%
Death Rate
Active Ingredients
CyphenothrinFipronil
Administration Routes
TopicalOralUnknown
Species Affected
Dog 109
Most Affected Breeds
Retriever - Labrador 13
Retriever - Golden 9
Maltese 8
Bichon Frise 6
Schnauzer - Miniature 5
Crossbred Canine/dog 5
Spaniel - Cocker American 5
Pit Bull 4
Shih Tzu 3
Mastiff 2
Most Reported Reactions
Lack of efficacy (ectoparasite) - flea 18
Vomiting 12
Lack of efficacy (flea) 11
Lethargy (see also Central nervous system depression in 'Neurological') 9
Restlessness 8
Itching 8
Agitation 6
INEFFECTIVE, HOOKS 6
Other abnormal test result NOS 6
Seizure NOS 6
Panting 5
Application site itching 5
Outcome Breakdown
Outcome Unknown
49 (45.0%)
Recovered/Normal
31 (28.4%)
Ongoing
24 (22.0%)
Euthanized
3 (2.8%)
Recovered with Sequela
2 (1.8%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.