Drug profile

The FDA adverse-event record for Hydromorphone Hcl Injectable

109 FDA reports name Hydromorphone Hcl Injectable, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#746 of 2,679
by report volume (all drugs)
109
adverse-event reports
21.1%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Hydromorphone Hcl Injectable ranks #744 of 2679 by total reports (109) and #223 of 1130 by death-coded share (21.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#744
This drug, reports of 2679
#223
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hydromorphone Hcl Injectable has 109 reports now versus 109 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hydromorphone Hcl Injectable changes

Signature read: death-coded report count at 23 is the most distinctive stamp on Hydromorphone Hcl Injectable's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
109
Total Reports
23
Deaths Reported
21.1%
Death-coded share of reports

Active Ingredients

Hydromorphone Hcl Injectable

Administration Routes

UnknownIntramuscularIntravenousSubcutaneous

Species Affected

Dog 101
Cat 6
Rabbit 2

Most Affected Breeds

Retriever - Labrador 10
Dog (unknown) 8
Chihuahua 8
Crossbred Canine/dog 5
Shepherd (unspecified) 4
Boxer (German Boxer) 4
Shepherd Dog - German 4
Domestic Shorthair 4
Terrier - Bull - American Pit 3
Bulldog - American 3

Most Reported Reactions

Vomiting 14
Death 14
Bradycardia 13
Lack of efficacy - NOS 13
Cardiac arrest 12
Lethargy (see also Central nervous system depression in 'Neurological') 10
Death by euthanasia 8
Anaphylaxis 8
Seizure NOS 7
Heart block NOS 6
Elevated total bilirubin 6
Panting 6

Outcome Breakdown

Recovered/Normal
43 (39.4%)
Ongoing
40 (36.7%)
Died
15 (13.8%)
Euthanized
8 (7.3%)
Outcome Unknown
3 (2.8%)

Hydromorphone Hcl Injectable: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Hydromorphone Hcl Injectable, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (21.1% here), distinct from the volume row.

What to do with this drug

  • Compare Hydromorphone Hcl Injectable's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hydromorphone Hcl Injectable (#746 of 2,679 by report volume); death-coded 21.1%. PlainBreed drug row · death-coded report count stamp 23 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →