Drug profile

The FDA adverse-event record for Zeranol Implant

109 FDA reports name Zeranol Implant, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#748 of 2,679
by report volume (all drugs)
109
adverse-event reports
32.1%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Zeranol Implant ranks #744 of 2679 by total reports (109) and #114 of 1130 by death-coded share (32.1%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#744
This drug, reports of 2679
#114
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Zeranol Implant has 109 reports now versus 109 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Zeranol Implant changes

Signature read: Zeranol Implant's 32.1% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
109
Total Reports
35
Deaths Reported
32.1%
Death-coded share of reports

Active Ingredients

Zeranol Implant

Administration Routes

UnknownSubcutaneousParenteralOther

Species Affected

Cattle 54
Unknown 49
Human 6

Most Affected Breeds

Unknown 55
Cattle (other) 22
Aberdeen Angus 11
Crossbred Bovine/Cattle 11
Red Angus 4
Holstein-Friesian also known as Holstein 3
Cattle (unknown) 1
Charolais 1
Cattle (unspecified) 1

Most Reported Reactions

Death 31
Lack of efficacy - NOS 18
Product problem 17
Uncoded sign 16
Device Defective NOS 15
Product Defect, General 12
Dispenser, Abnormal 9
Lack of efficacy (bacteria) - NOS 7
Containers, Damaged 7
Difficulty of Use 6
Implant, Abnormal 5
Necropsy performed 5

Outcome Breakdown

Died
34 (38.2%)
Ongoing
20 (22.5%)
Outcome Unknown
18 (20.2%)
Recovered/Normal
13 (14.6%)
Euthanized
3 (3.4%)
Recovered with Sequela
1 (1.1%)

Zeranol Implant: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Zeranol Implant, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (32.1% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Zeranol Implant (#748 of 2,679 by report volume); death-coded 32.1%. PlainBreed drug row · death-coded share stamp 32.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →