Imidacloprid + Permethrin + N-Methylpyrolidone
253 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
253
Total Reports
7
Deaths Reported
280.0%
Death Rate
Active Ingredients
Imidacloprid + Permethrin + N-Methylpyrolidone
Administration Routes
TopicalUnknownOralCutaneousOther
Species Affected
Dog 251
Unknown 1
Cat 1
Most Affected Breeds
Retriever - Labrador 35
Retriever - Golden 14
Chihuahua 13
Crossbred Canine/dog 12
Dog (unknown) 10
Shih Tzu 9
Shepherd Dog - German 7
Pit Bull 7
Boxer (German Boxer) 7
Shepherd Dog - Australian 7
Most Reported Reactions
Lethargy (see also Central nervous system depression in 'Neurological') 53
Lack of efficacy (ectoparasite) - flea 48
Emesis 45
Vomiting 40
Lack of efficacy - NOS 31
Other abnormal test result NOS 17
Behavioural disorder NOS 12
INEFFECTIVE, HOOKS 9
Not eating 8
Seizure NOS 8
Diarrhoea 8
Decreased appetite 8
Outcome Breakdown
Recovered/Normal
106 (42.1%)
Outcome Unknown
98 (38.9%)
Ongoing
31 (12.3%)
Recovered with Sequela
10 (4.0%)
Died
6 (2.4%)
Euthanized
1 (0.4%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.