Drug profile

The FDA adverse-event record for Aspirin

217 FDA reports name Aspirin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#520 of 2,679
by report volume (all drugs)
217
adverse-event reports
24.0%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Aspirin ranks #520 of 2679 by total reports (217) and #184 of 1130 by death-coded share (24.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#520
This drug, reports of 2679
#184
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Aspirin has 217 reports now versus 216 in that prior snapshot: 1 more (0.5%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Aspirin changes

Signature read: death-coded report count at 52 is the most distinctive stamp on Aspirin's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
217
Total Reports
52
Deaths Reported
24.0%
Death-coded share of reports

Active Ingredients

Aspirin

Administration Routes

OralUnknown

Species Affected

Dog 158
Human 41
Cat 14
Pig 3
Cattle 1

Most Affected Breeds

Unknown 41
Retriever - Labrador 29
Boxer (German Boxer) 8
Retriever - Golden 6
Pit Bull 6
Terrier - Jack Russell 5
Shepherd Dog - German 5
Shepherd (unspecified) 5
Beagle 4
Retriever (unspecified) 4

Most Reported Reactions

Vomiting 40
Death by euthanasia 36
Diarrhoea 30
Lethargy (see also Central nervous system depression in 'Neurological') 26
Accidental exposure 25
Anorexia 25
Other abnormal test result NOS 24
Emesis 19
Weight loss 17
Decreased appetite 15
Anaemia NOS 15
Seizure NOS 14

Outcome Breakdown

Recovered/Normal
62 (28.6%)
Outcome Unknown
50 (23.0%)
Euthanized
37 (17.1%)
Ongoing
35 (16.1%)
Recovered with Sequela
17 (7.8%)
Died
16 (7.4%)

Aspirin: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Aspirin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (24.0% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Aspirin (#520 of 2,679 by report volume); death-coded 24.0%. PlainBreed drug row · death-coded report count stamp 52 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →