Drug profile

The FDA adverse-event record for Eprinomectin

1,013 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Eprinomectin. See the species affected, top reactions, and outcomes below.

1,013
adverse-event reports
23.5%
death-coded share
Cattle
most-reported species
214
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,013
Total Reports
238
Deaths Reported
23.5%
Death Rate

Active Ingredients

Eprinomectin

Administration Routes

UnknownTopicalSubcutaneousOtherOralIntramuscularRespiratory (Inhalation)ParenteralIntradermalIntra-Amniotic

Species Affected

Cattle 751
Unknown 154
Human 49
Dog 37
Cat 6
Sheep 5
Horse 4
Deer 2
Goat 2
Alpaca 1

Most Affected Breeds

Cattle (other) 308
Unknown 213
Cattle (unknown) 162
Aberdeen Angus 105
Holstein-Friesian also known as Holstein 77
Crossbred Bovine/Cattle 30
Charolais 10
Collie - Border 9
Hereford cattle 9
Mixed (Cattle) 6

Most Reported Reactions

Death 214
Lack of efficacy - NOS 111
Lack of efficacy (endoparasite) - NOS 84
Lack of efficacy (lice) 83
Accidental exposure 49
Lack of efficacy (ectoparasite) - NOS 47
Lack of efficacy (ectoparasite) - lice 44
Vials, Leaking 28
Unclassifiable adverse event 26
Pruritus 25
Recumbency 24
Lack of efficacy (endoparasite) - Trichostrongylus 24

Outcome Breakdown

Outcome Unknown
403 (47.6%)
Died
226 (26.7%)
Recovered/Normal
128 (15.1%)
Ongoing
61 (7.2%)
Euthanized
15 (1.8%)
Recovered with Sequela
14 (1.7%)

Eprinomectin Adverse Event Insights

1,013 reports name Eprinomectin; 238 recorded a death outcome (23.5% of reported events, not a population-level mortality rate). Active ingredient: Eprinomectin. Administration routes: Unknown, Topical, Subcutaneous, Other.

By species: Cattle (751 reports), Unknown (154 reports), Human (49 reports). By breed: Cattle (other) (308), Unknown (213), Cattle (unknown) (162).

Leading clinical signs: Death (214), Lack of efficacy - NOS (111), Lack of efficacy (endoparasite) - NOS (84), Lack of efficacy (lice) (83). Outcome, 847 coded reports: Outcome Unknown leads at 47.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.