Drug profile

The FDA adverse-event record for Eprinomectin

1,030 FDA reports name Eprinomectin, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#177 of 2,679
by report volume (all drugs)
1,030
adverse-event reports
23.9%
death-coded share
Cattle
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Eprinomectin ranks #177 of 2679 by total reports (1,030) and #187 of 1130 by death-coded share (23.9%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#177
This drug, reports of 2679
#187
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Eprinomectin has 1,030 reports now versus 1,023 in that prior snapshot: 7 more (0.7%).

Report change
+7
Death-coded reports
+2
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Eprinomectin changes

Signature read: death-coded report count at 246 is the most distinctive stamp on Eprinomectin's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,030
Total Reports
246
Deaths Reported
23.9%
Death-coded share of reports

Active Ingredients

Eprinomectin

Administration Routes

UnknownTopicalSubcutaneousOtherOralIntramuscularRespiratory (Inhalation)ParenteralIntradermalIntra-Amniotic

Species Affected

Cattle 764
Unknown 156
Human 49
Dog 37
Cat 7
Sheep 5
Horse 4
Goat 3
Deer 2
Alpaca 1

Most Affected Breeds

Cattle (other) 312
Unknown 215
Cattle (unknown) 164
Aberdeen Angus 107
Holstein-Friesian also known as Holstein 79
Crossbred Bovine/Cattle 32
Charolais 10
Collie - Border 9
Hereford cattle 9
Mixed (Cattle) 7

Most Reported Reactions

Death 220
Lack of efficacy - NOS 112
Lack of efficacy (endoparasite) - NOS 84
Lack of efficacy (lice) 83
Accidental exposure 49
Lack of efficacy (ectoparasite) - NOS 48
Lack of efficacy (ectoparasite) - lice 46
Vials, Leaking 28
Unclassifiable adverse event 26
Recumbency 26
Pruritus 25
Lack of efficacy (endoparasite) - Trichostrongylus 24

Outcome Breakdown

Outcome Unknown
409 (47.4%)
Died
233 (27.0%)
Recovered/Normal
130 (15.1%)
Ongoing
61 (7.1%)
Euthanized
16 (1.9%)
Recovered with Sequela
14 (1.6%)

Eprinomectin: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Eprinomectin, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (23.9% here), distinct from the volume row.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Eprinomectin (#177 of 2,679 by report volume); death-coded 23.9%. PlainBreed drug row · death-coded report count stamp 246 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →