Drug profile

The FDA adverse-event record for Recombitek C8 - 47K9.R0

216 FDA reports name Recombitek C8 - 47K9.R0, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#522 of 2,679
by report volume (all drugs)
216
adverse-event reports
9.3%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Recombitek C8 - 47K9.R0 ranks #522 of 2679 by total reports (216) and #580 of 1130 by death-coded share (9.3%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#522
This drug, reports of 2679
#580
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Recombitek C8 - 47K9.R0 has 216 reports now versus 212 in that prior snapshot: 4 more (1.9%).

Report change
+4
Death-coded reports
+1
Death-coded share
+0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Recombitek C8 - 47K9.R0 changes

Signature read: 216 reports place Recombitek C8 - 47K9.R0 in the upper third of FDA AER volume (#522 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
216
Total Reports
20
Deaths Reported
9.3%
Death-coded share of reports

Active Ingredients

Recombitek C8 - 47K9.R0

Administration Routes

SubcutaneousUnknownOral

Species Affected

Dog 216

Most Affected Breeds

Retriever - Labrador 18
Shih Tzu 15
Retriever - Golden 14
Chihuahua 11
Shepherd Dog - German 10
Shepherd Dog - Australian 9
Dachshund (unspecified) 9
Pit Bull 9
Spaniel - King Charles Cavalier 7
Terrier - Yorkshire 7

Most Reported Reactions

Vomiting 53
Injection site pain 34
Diarrhoea 24
Lethargy (see also Central nervous system depression in Neurological) 24
Injection site swelling 23
Lethargy (see also Central nervous system depression in 'Neurological') 22
Injection site lump 20
Anorexia 16
Seizure NOS 14
Pain NOS 13
Death 13
Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 12

Outcome Breakdown

Outcome Unknown
94 (43.3%)
Recovered/Normal
82 (37.8%)
Ongoing
21 (9.7%)
Died
13 (6.0%)
Euthanized
7 (3.2%)

Recombitek C8 - 47K9.R0: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Recombitek C8 - 47K9.R0, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

  • Compare Recombitek C8 - 47K9.R0's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Recombitek C8 - 47K9.R0 (#522 of 2,679 by report volume); death-coded 9.3%. PlainBreed drug row · report volume stamp 216 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →