Drug profile

The FDA adverse-event record for Dhlpp Vaccine

202 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Dhlpp Vaccine. See the species affected, top reactions, and outcomes below.

202
adverse-event reports
11.9%
death-coded share
Dog
most-reported species
49
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
202
Total Reports
24
Deaths Reported
11.9%
Death Rate

Active Ingredients

Dhlpp Vaccine

Administration Routes

ParenteralUnknownSubcutaneousRespiratory (Inhalation)Cutaneous

Species Affected

Dog 201
Human 1

Most Affected Breeds

Retriever - Labrador 31
Chihuahua 12
Shepherd Dog - German 11
Crossbred Canine/dog 10
Retriever - Golden 10
Pit Bull 9
Shih Tzu 6
Shepherd Dog - Australian 6
Boxer (German Boxer) 6
Maltese 6

Most Reported Reactions

Vomiting 49
Lethargy (see also Central nervous system depression in 'Neurological') 41
Emesis 32
Other abnormal test result NOS 20
Diarrhoea 19
Behavioural disorder NOS 16
Seizure NOS 15
Lack of efficacy (endoparasite) - heartworm 14
Death 12
Lack of efficacy - NOS 10
Shaking 10
Weight loss 10

Outcome Breakdown

Recovered/Normal
86 (42.6%)
Outcome Unknown
51 (25.2%)
Ongoing
33 (16.3%)
Died
18 (8.9%)
Recovered with Sequela
8 (4.0%)
Euthanized
6 (3.0%)

Dhlpp Vaccine Adverse Event Insights

202 reports name Dhlpp Vaccine; 24 recorded a death outcome (11.9% of reported events, not a population-level mortality rate). Active ingredient: Dhlpp Vaccine. Administration routes: Parenteral, Unknown, Subcutaneous, Respiratory (Inhalation).

By species: Dog (201 reports), Human (1 reports). By breed: Retriever - Labrador (31), Chihuahua (12), Shepherd Dog - German (11).

Leading clinical signs: Vomiting (49), Lethargy (see also Central nervous system depression in 'Neurological') (41), Emesis (32), Other abnormal test result NOS (20). Outcome, 202 coded reports: Recovered/Normal leads at 42.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.