Drug profile

The FDA adverse-event record for Dhlpp Vaccine

215 FDA reports name Dhlpp Vaccine, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#523 of 2,679
by report volume (all drugs)
215
adverse-event reports
11.2%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Dhlpp Vaccine ranks #523 of 2679 by total reports (215) and #497 of 1130 by death-coded share (11.2%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#523
This drug, reports of 2679
#497
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Dhlpp Vaccine has 215 reports now versus 209 in that prior snapshot: 6 more (2.9%).

Report change
+6
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Dhlpp Vaccine changes

Signature read: death-coded report count at 24 is the most distinctive stamp on Dhlpp Vaccine's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
215
Total Reports
24
Deaths Reported
11.2%
Death-coded share of reports

Active Ingredients

Dhlpp Vaccine

Administration Routes

ParenteralUnknownSubcutaneousRespiratory (Inhalation)Cutaneous

Species Affected

Dog 214
Human 1

Most Affected Breeds

Retriever - Labrador 31
Chihuahua 13
Crossbred Canine/dog 11
Shepherd Dog - German 11
Retriever - Golden 10
Pit Bull 9
Shih Tzu 7
Shepherd Dog - Australian 6
Boxer (German Boxer) 6
Maltese 6

Most Reported Reactions

Vomiting 51
Lethargy (see also Central nervous system depression in 'Neurological') 41
Emesis 32
Diarrhoea 21
Other abnormal test result NOS 20
Behavioural disorder NOS 16
Seizure NOS 16
Lack of efficacy (endoparasite) - heartworm 14
Death 12
Lack of efficacy - NOS 12
Shaking 10
Weight loss 10

Outcome Breakdown

Recovered/Normal
89 (41.4%)
Outcome Unknown
57 (26.5%)
Ongoing
37 (17.2%)
Died
18 (8.4%)
Recovered with Sequela
8 (3.7%)
Euthanized
6 (2.8%)

Dhlpp Vaccine: high report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Dhlpp Vaccine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Dhlpp Vaccine (#523 of 2,679 by report volume); death-coded 11.2%. PlainBreed drug row · death-coded report count stamp 24 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →