Reaction profile

The FDA adverse-event record for anal sac disorder

558 FDA reports name anal sac disorder, a high-volume reaction in the CVM extract (VeDDRA 1999). Plate stamps and neighbourhood peers follow.

#600 of 2,481
by report volume (all reactions)
558
reports citing this reaction
7.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Anal sac disorder has 558 reports now versus 554 in that prior snapshot: 4 more (0.7%).

Report change
+4
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Anal sac disorder changes

FDA AER · VeDDRA plate

Code 1999 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 558 reports
  • DEATH-PAR 7.7%
  • UPPER-Q #600/2481
  • PHOTO-FINISH Drunken gait
  • SPECIES-DOG Dog · 535
  • DRUG-LEAD Milbemycin Oxime… · 101
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Drunken gait (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Anal sac disorder

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Syringe, Abnormal · near561Whining · near561Anal sac disorder · this rea…558Drunken gait · near558Impaired consciousness · near558Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Anal sac disorder

Anal sac disorder: low death-coded share in the FDA AER plate

Signature read: 558 reports place Anal sac disorder in the upper third of FDA AER volume (#600 of 2,481). Report volume is upper-third scale: 558 named reports in the openFDA extract. Death-coded share is lower-third: 43 of 558 reports (7.7% of named reports). Nearest volume peer: Drunken gait (±0 reports). Lead species Dog (535). Lead co-reported drug Milbemycin Oxime + Spinosad (101).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 535
Cat 23

Breeds Most Affected

Retriever - Labrador 46
Crossbred Canine/dog 32
Chihuahua 29
Beagle 25
Shih Tzu 21
Retriever - Golden 21
Terrier - Yorkshire 19
Shepherd Dog - German 16
Domestic Shorthair 16
Dog (unknown) 15

Associated Drugs

Milbemycin Oxime + Spinosad 101
Oclacitinib Maleate 59
Milbemycin Oxime + Praziquantel 45
Afoxolaner 43
Trilostane 32
Ivermectin + Pyrantel As Pamoate Salt 27
Fluralaner Chew Tablets 26
Maropitant Citrate 23
Carprofen 22
Spinosad 21
Imidacloprid + Moxidectin 17
Enrofloxacin 17
Fluralaner 13.64% 12-Week Chew 17
Anti-Il31 Mab Mcs Lot #1283563 16
Moxidectin 15
Bedinvetmab 15
Sarolaner 14
Polysulfated Glycosaminoglycan 13
Gabapentin 13
Pyrantel Pamoate;Sarolaner 12

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Anal sac disorder, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (558 here).

Similar death-coded share

Nearest other reactions by death-coded share (7.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Anal sac disorder (#600 of 2,481 by report volume); death-coded 7.7%. PlainBreed reaction plate · report volume stamp 558 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →