Reaction profile

The FDA adverse-event record for cachexia

95 FDA adverse-event reports reference cachexia (VeDDRA 1051). See the species, breeds, and drugs most associated with it below.

95
reports citing this reaction
61.1%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
95
Total Reports
58
Deaths
61.1%
Death Rate

Species Most Affected

Dog 57
Cat 27
Cattle 6
Sheep 2
Horse 1
Quail 1
Ferret 1

Breeds Most Affected

Domestic Shorthair 15
Crossbred Canine/dog 7
Retriever - Labrador 5
Dachshund (unspecified) 4
Chihuahua 4
Cattle (other) 3
Terrier - Boston 3
Terrier - Yorkshire 3
Pit Bull 2
Terrier - Jack Russell 2

Associated Drugs

Trilostane 11
Spinosad 10
Maropitant Citrate 8
Enrofloxacin 6
Cefovecin 5
Prednisone 5
Clindamycin 4
Maropitant 4
Frunevetmab 4
Selamectin 3
Gamithromycin 3
Milbemycin Oxime + Spinosad 3
Vitamin B12 3
Famotidine 3
Cephalexin 3
Dexamethasone 3
Metronidazole 3
Bedinvetmab 3
Pyrantel Pamoate 2
Melarsomine Dihydrochloride 2

Cachexia Reaction Insights

95 reports name Cachexia; 58 recorded a death outcome (61.1% of reported events, not a population-level mortality rate). VeDDRA code: 1051.

By species: Dog (57 reports), Cat (27 reports), Cattle (6 reports). By breed: Domestic Shorthair (15), Crossbred Canine/dog (7), Retriever - Labrador (5).

Most co-reported drugs: Trilostane (11 reports), Spinosad (10 reports), Maropitant Citrate (8 reports), Enrofloxacin (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.