Reaction profile

The FDA adverse-event record for eyelid inflammation

85 FDA adverse-event reports reference eyelid inflammation (VeDDRA 422). See the species, breeds, and drugs most associated with it below.

85
reports citing this reaction
3.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
85
Total Reports
3
Deaths
3.5%
Death Rate

Species Most Affected

Dog 63
Cat 13
Human 5
Horse 2
Cattle 2

Breeds Most Affected

Domestic Shorthair 10
Retriever - Labrador 8
Boxer (German Boxer) 7
Crossbred Canine/dog 6
Unknown 5
Terrier - Yorkshire 4
Domestic Mediumhair 3
Chihuahua 3
Shih Tzu 2
Terrier (unspecified) 2

Associated Drugs

Milbemycin Oxime + Spinosad 19
Afoxolaner 7
Selamectin 6
Bordetella Vaccine 6
Oclacitinib Maleate 5
Fluralaner Chew Tablets 4
Leptospirosis Vaccine 4
Ivermectin + Pyrantel As Pamoate Salt 3
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 3
Oclacitinib 3
Prednisone 3
Midazolam 3
Spinosad 2
Cyclosporine A 2
Marbofloxacin 2
Diphenhydramine Hcl 2
Doxycycline 2
Terbutaline 2
Rabies In Hhh Adj Pfizer Kv 2
Fluralaner Spot-On Solution 2

Eyelid inflammation Reaction Insights

85 reports name Eyelid inflammation; 3 recorded a death outcome (3.5% of reported events, not a population-level mortality rate). VeDDRA code: 422.

By species: Dog (63 reports), Cat (13 reports), Human (5 reports). By breed: Domestic Shorthair (10), Retriever - Labrador (8), Boxer (German Boxer) (7).

Most co-reported drugs: Milbemycin Oxime + Spinosad (19 reports), Afoxolaner (7 reports), Selamectin (6 reports), Bordetella Vaccine (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.