Reaction profile

The FDA adverse-event record for lack of efficacy (protozoa) - ehrlichia

251 FDA adverse-event reports reference lack of efficacy (protozoa) - ehrlichia (VeDDRA 2805). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#937 of 2,481
by report volume (all reactions)
251
reports citing this reaction
1.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (protozoa) - Ehrlichia has 251 reports now versus 251 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (protozoa) - Ehrlichia changes

FDA AER · VeDDRA plate

Code 2805 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 251 reports
  • DEATH-LOW 1.2%
  • MID-PACK #937/2481
  • PHOTO-FINISH Gastric ulceration NOS
  • SPECIES-DOG Dog · 251
  • DRUG-LEAD Afoxolaner · 91
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Gastric ulceration NOS (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Lack of efficacy - Ehrlichia

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Congested mucous memb… · near252Gastric ulceration NOS · near251Injected sclera · near251Lack of efficacy (pro… · thi…251Skin abscess · near251Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of efficacy (protozoa) - Ehrlichia

Lack of efficacy (protozoa) - Ehrlichia: low death-coded share in the FDA AER plate

Signature read: Lack of efficacy (protozoa) - Ehrlichia's 1.2% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 3 of 251 reports (1.2% of named reports). Nearest volume peer: Gastric ulceration NOS (±0 reports). Lead species Dog (251). Lead co-reported drug Afoxolaner (91).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 251

Breeds Most Affected

Retriever - Labrador 41
Crossbred Canine/dog 26
Dog (unknown) 18
Retriever - Golden 18
Shepherd Dog - German 17
Terrier (unspecified) 10
Hound (unspecified) 8
Beagle 8
Shih Tzu 6
Shepherd Dog - Australian 6

Associated Drugs

Afoxolaner 91
Fluralaner 13.64% 12-Week Chew 56
Pyrantel Pamoate;Sarolaner 47
Sarolaner 39
Lotilaner 23
Ivermectin + Pyrantel As Pamoate Salt 8
Milbemycin Oxime + Praziquantel 7
Selamectin 3
Fluralaner Chew Tablets 2
Doxycycline 2
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 2
Milbemycin/Praziquantel 2
Borrelia Burgdorferi Bacterin 1
Leptospira-Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 1
Milbemycin/Lufenuron Tablets 1
Lyme Vaccine 1
Ivermectin + Pyrantel 1
Fipronil + Permethrin + Pyriproxifen 1
Glucosamine 1
Moxidectin 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lack of efficacy (protozoa) - Ehrlichia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (251 here).

Similar death-coded share

Nearest other reactions by death-coded share (1.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (protozoa) - Ehrlichia (#937 of 2,481 by report volume); death-coded 1.2%. PlainBreed reaction plate · death-coded share stamp 1.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →