Unusual stool colour

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VeDDRA Code: 2435

229 adverse event reports referencing this reaction

229
Total Reports
30
Deaths
1310.0%
Death Rate

Species Most Affected

Dog 206
Cat 20
Horse 2
Ferret 1

Breeds Most Affected

Retriever - Labrador 21
Crossbred Canine/dog 18
Domestic Shorthair 15
Shih Tzu 10
Shepherd Dog - German 9
Retriever - Golden 9
Chihuahua 8
Dog (unknown) 8
Collie - Border 7
Beagle 5

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 27
Afoxolaner 20
Maropitant Citrate 18
Fluralaner Chew Tablets 16
Milbemycin Oxime + Praziquantel 15
Pyrantel Pamoate;Sarolaner 14
Milbemycin Oxime + Spinosad 13
Carprofen 12
Gabapentin 12
Oclacitinib Maleate 9
Fluralaner 13.64% 12-Week Chew 9
Bedinvetmab 9
Grapiprant 8
Lotilaner 8
Moxidectin 8
Prednisone 6
Praziquantel + Pyrantel Pamoate 6
Famotidine 6
Sucralfate 6
Enrofloxacin 6

Data Summary

Metric Value
Total reports referencing reaction 229
Reports with fatal outcome 30
Case-fatality rate (reported events) 1310.0%
Species observed 4
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2435.

Unusual stool colour Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 229 adverse event reports that reference Unusual stool colour as a reaction term, including 30 reports with a death outcome — a 1310.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2435, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Unusual stool colour appears most frequently in reports for Dog (206 reports), Cat (20 reports), Horse (2 reports) — with Dog dominating at 206 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (21), Crossbred Canine/dog (18), Domestic Shorthair (15). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Unusual stool colour are Ivermectin + Pyrantel As Pamoate Salt (27 reports), Afoxolaner (20 reports), Maropitant Citrate (18 reports), Fluralaner Chew Tablets (16 reports), with Ivermectin + Pyrantel As Pamoate Salt appearing alongside this reaction in 27 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial