Reaction profile

The FDA adverse-event record for unusual stool colour

229 FDA adverse-event reports reference unusual stool colour (VeDDRA 2435). See the species, breeds, and drugs most associated with it below.

229
reports citing this reaction
13.1%
death-coded share
Dog
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
229
Total Reports
30
Deaths
13.1%
Death Rate

Species Most Affected

Dog 206
Cat 20
Horse 2
Ferret 1

Breeds Most Affected

Retriever - Labrador 21
Crossbred Canine/dog 18
Domestic Shorthair 15
Shih Tzu 10
Shepherd Dog - German 9
Retriever - Golden 9
Chihuahua 8
Dog (unknown) 8
Collie - Border 7
Beagle 5

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 27
Afoxolaner 20
Maropitant Citrate 18
Fluralaner Chew Tablets 16
Milbemycin Oxime + Praziquantel 15
Pyrantel Pamoate;Sarolaner 14
Milbemycin Oxime + Spinosad 13
Carprofen 12
Gabapentin 12
Oclacitinib Maleate 9
Fluralaner 13.64% 12-Week Chew 9
Bedinvetmab 9
Grapiprant 8
Lotilaner 8
Moxidectin 8
Prednisone 6
Praziquantel + Pyrantel Pamoate 6
Famotidine 6
Sucralfate 6
Enrofloxacin 6

Unusual stool colour Reaction Insights

229 reports name Unusual stool colour; 30 recorded a death outcome (13.1% of reported events, not a population-level mortality rate). VeDDRA code: 2435.

By species: Dog (206 reports), Cat (20 reports), Horse (2 reports). By breed: Retriever - Labrador (21), Crossbred Canine/dog (18), Domestic Shorthair (15).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (27 reports), Afoxolaner (20 reports), Maropitant Citrate (18 reports), Fluralaner Chew Tablets (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.