Reaction profile
The FDA adverse-event record for foaming at the mouth
3,446 FDA adverse-event reports reference foaming at the mouth (VeDDRA 1074). See the species, breeds, and drugs most associated with it below.
- 3,446
- reports citing this reaction
- 11.5%
- death-coded share
- Cat
- most-affected species
- Fluralaner Spot-On Solution
- most-associated drug
Species Most Affected
Breeds Most Affected
Associated Drugs
Foaming at the mouth Reaction Insights
3,446 reports name Foaming at the mouth; 398 recorded a death outcome (11.5% of reported events, not a population-level mortality rate). VeDDRA code: 1074.
By species: Cat (1,736 reports), Dog (1,593 reports), Cattle (86 reports). By breed: Domestic Shorthair (1,082), Cat (unknown) (204), Retriever - Labrador (170).
Most co-reported drugs: Fluralaner Spot-On Solution (480 reports), Afoxolaner (308 reports), Milbemycin Oxime + Spinosad (244 reports), Eprinomectin + Esafoxolaner + Praziquantel (203 reports).
Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.