Reaction profile

The FDA adverse-event record for limb weakness

3,426 FDA adverse-event reports reference limb weakness (VeDDRA 1121). See the species, breeds, and drugs most associated with it below.

3,426
reports citing this reaction
17.7%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
3,426
Total Reports
607
Deaths
17.7%
Death Rate

Species Most Affected

Dog 3,061
Cat 331
Horse 12
Cattle 8
Pig 5
Human 4
Ferret 3
Other Birds 1
Cougar 1

Breeds Most Affected

Retriever - Labrador 473
Domestic Shorthair 210
Crossbred Canine/dog 200
Shepherd Dog - German 167
Retriever - Golden 165
Boxer (German Boxer) 102
Dog (unknown) 86
Shih Tzu 72
Terrier - Yorkshire 68
Shepherd Dog - Australian 67

Associated Drugs

Bedinvetmab 1,011
Gabapentin 384
Trilostane 315
Carprofen 312
Milbemycin Oxime + Spinosad 204
Afoxolaner 151
Fluralaner Chew Tablets 128
Prednisone 126
Grapiprant 120
Maropitant Citrate 117
Pyrantel Pamoate;Sarolaner 117
Fluralaner 13.64% 12-Week Chew 112
Oclacitinib Maleate 104
Sarolaner 103
Polysulfated Glycosaminoglycan 102
Frunevetmab 102
Moxidectin 77
Enrofloxacin 74
Tramadol 69
Meloxicam 67

Limb weakness Reaction Insights

3,426 reports name Limb weakness; 607 recorded a death outcome (17.7% of reported events, not a population-level mortality rate). VeDDRA code: 1121.

By species: Dog (3,061 reports), Cat (331 reports), Horse (12 reports). By breed: Retriever - Labrador (473), Domestic Shorthair (210), Crossbred Canine/dog (200).

Most co-reported drugs: Bedinvetmab (1,011 reports), Gabapentin (384 reports), Trilostane (315 reports), Carprofen (312 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.